Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis

K Ghoreschi, A Balato, C Enerbäck, R Sabat - The Lancet, 2021 - thelancet.com
Psoriasis is a chronic inflammatory disease characterised by sharply demarcated
erythematous and scaly skin lesions accompanied by systemic manifestations. Classified by …

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics

A Menter, BE Strober, DH Kaplan, D Kivelevitch… - Journal of the American …, 2019 - Elsevier
Psoriasis is a chronic, inflammatory multisystem disease that affects up to 3.2% of the US
population. This guideline addresses important clinical questions that arise in psoriasis …

[HTML][HTML] Guselkumab for the treatment of Crohn's disease: induction results from the phase 2 GALAXI-1 study

WJ Sandborn, GR D'Haens, W Reinisch, J Panés… - Gastroenterology, 2022 - Elsevier
Background & Aims Guselkumab, a selective p19 interleukin-23 antagonist, is approved for
the treatment of plaque psoriasis and psoriatic arthritis. This study evaluated the efficacy and …

Systemic pharmacological treatments for chronic plaque psoriasis: a network meta‐analysis

E Sbidian, A Chaimani, R Guelimi… - Cochrane Database …, 2023 - cochranelibrary.com
Background Psoriasis is an immune‐mediated disease with either skin or joints
manifestations, or both, and it has a major impact on quality of life. Although there is …

Discovery of the IL-23/IL-17 signaling pathway and the treatment of psoriasis

JE Hawkes, BY Yan, TC Chan… - The Journal of …, 2018 - journals.aai.org
Psoriasis vulgaris is a common, heterogeneous, chronic inflammatory skin disease
characterized by thickened, red, scaly plaques and systemic inflammation. Psoriasis is also …

Psoriasis pathogenesis and the development of novel targeted immune therapies

JE Hawkes, TC Chan, JG Krueger - Journal of Allergy and Clinical …, 2017 - Elsevier
Psoriasis is caused by a complex interplay between the immune system, psoriasis-
associated susceptibility loci, autoantigens, and multiple environmental factors. Over the last …

IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting

AR Moschen, H Tilg, T Raine - Nature Reviews Gastroenterology & …, 2019 - nature.com
Abstract IL-12 and IL-23 are closely related cytokines with important roles in the regulation of
tissue inflammation. Converging evidence from studies in mice, human observational …

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

HM Knochelmann, CJ Dwyer, SR Bailey… - Cellular & molecular …, 2018 - nature.com
The balance between Th17 cells and regulatory T cells (Tregs) has emerged as a prominent
factor in regulating autoimmunity and cancer. Th17 cells are vital for host defense against …

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities

CA Elmets, CL Leonardi, DMR Davis… - Journal of the American …, 2019 - Elsevier
Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with
awareness and attention to comorbidities - ScienceDirect Skip to main contentSkip to article …

Drug survival associated with effectiveness and safety of treatment with guselkumab, ixekizumab, secukinumab, ustekinumab, and adalimumab in patients with …

ZZN Yiu, G Becher, B Kirby, P Laws… - JAMA …, 2022 - jamanetwork.com
Importance Drug survival of biologic therapies for psoriasis is a proxy for longer-term
treatment effectiveness and safety. Patient factors that are associated with the survival of …