The Notch signaling pathway plays major roles in organ development across animal
species. In the mammalian liver, Notch has been found critical in development, regeneration …

The liver is one of the few organs that retain the capability to regenerate in adult mammals.
This regeneration process is mainly facilitated by the dynamic behavior of hepatocytes …

Background Effective treatments for acute-on-chronic liver failure (ACLF) are lacking.
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been applied in …

Despite the robust healing capacity of the liver, regenerative failure underlies numerous
hepatic diseases, including the JAG1 haploinsufficient disorder, Alagille syndrome (ALGS) …

In the adult liver, a population of facultative progenitor cells called biliary epithelial cells
(BECs) proliferate and differentiate into cholangiocytes and hepatocytes after injury, thereby …

Background and Aims The liver is a highly regenerative organ, but its regenerative capacity
is compromised in severe liver injury settings. In chronic liver diseases, the number of liver …

Regeneration is an evolutionarily conserved process in animal kingdoms, however, the
regenerative capacities differ from species and organ/tissues. Mammals possess very …

A wealth of studies over several decades has revealed an epigenetic prepattern that
determines the competence of cellular differentiation in the developing liver. More recently …

Abstract Background & Aims Alagille syndrome (ALGS) manifests with peripheral
intrahepatic bile duct (IHBD) paucity, which can spontaneously resolve. In a model for ALGS …

In cases of extensive liver injury, biliary epithelial cells (BECs) dedifferentiate into bipotential
progenitor cells (BPPCs), then redifferentiate into hepatocytes and BECs to accomplish liver …