Tempering aversive/traumatic memories with cannabinoids: a review of evidence from animal and human studies
Rationale Aversive learning and memory are essential to cope with dangerous and stressful
stimuli present in an ever-changing environment. When this process is dysfunctional …
stimuli present in an ever-changing environment. When this process is dysfunctional …
Cannabinoid receptor interacting protein 1a (CRIP1a): function and structure
WT Booth, NB Walker, WT Lowther, AC Howlett - Molecules, 2019 - mdpi.com
Cannabinoid receptor interacting protein 1a (CRIP1a) is an important CB1 cannabinoid
receptor-associated protein, first identified from a yeast two-hybrid screen to modulate CB1 …
receptor-associated protein, first identified from a yeast two-hybrid screen to modulate CB1 …
Cannabinoid CB1 receptor calibrates excitatory synaptic balance in the mouse hippocampus
The endocannabinoid system negatively regulates the release of various neurotransmitters
in an activity-dependent manner, thereby influencing the excitability of neuronal circuits. In …
in an activity-dependent manner, thereby influencing the excitability of neuronal circuits. In …
Cannabinoid receptor gene CNR1 is downregulated in subcortical brain samples and upregulated in blood samples of individuals with schizophrenia: A participant …
S Bloch Priel, A Yitzhaky, D Gurwitz… - European Journal of …, 2023 - Wiley Online Library
Cannabis use leads to symptom exacerbation in schizophrenia patients, and
endocannabinoid ligands have been studied as tentative schizophrenia therapeutics. Here …
endocannabinoid ligands have been studied as tentative schizophrenia therapeutics. Here …
Targeting brain and peripheral plasticity of the lipidome in acute kainic acid-induced epileptic seizures in mice via quantitative mass spectrometry
R Lerner, J Post, S Loch, B Lutz, L Bindila - Biochimica et Biophysica Acta …, 2017 - Elsevier
Epilepsy is a highly common chronic neurological disorder, manifested in many different
types, affecting~ 1% of the worldwide human population. The molecular mechanisms of …
types, affecting~ 1% of the worldwide human population. The molecular mechanisms of …
Cannabinoid receptor–interacting protein 1a modulates CB1 receptor signaling and regulation
TH Smith, LC Blume, A Straiker, JO Cox, BG David… - Molecular …, 2015 - ASPET
Cannabinoid CB1 receptors (CB1Rs) mediate the presynaptic effects of endocannabinoids
in the central nervous system (CNS) and most behavioral effects of exogenous …
in the central nervous system (CNS) and most behavioral effects of exogenous …
Analysis in conditional cannabinoid 1 receptor-knockout mice reveals neuronal subpopulation-specific effects on epileptogenesis in the kindling paradigm
EL Von Rüden, M Jafari, RM Bogdanovic… - Neurobiology of …, 2015 - Elsevier
The endocannabinoid system serves as a retrograde negative feedback mechanism. It is
thought to control neuronal activity in an epileptic neuronal network. The purpose of this …
thought to control neuronal activity in an epileptic neuronal network. The purpose of this …
CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations
Drugs that modulate the endocannabinoid system and endocannabinoids typically play an
anticonvulsant role although some proconvulsant effects have been reported both in …
anticonvulsant role although some proconvulsant effects have been reported both in …
Orexin receptor multimerization versus functional interactions: Neuropharmacological implications for opioid and cannabinoid signalling and pharmacogenetics
Orexins/hypocretins are neuropeptides formed by proteolytic cleavage of a precursor
peptide, which are produced by neurons found in the lateral hypothalamus. The G protein …
peptide, which are produced by neurons found in the lateral hypothalamus. The G protein …
Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus
S Guggenhuber, A Alpar, R Chen, N Schmitz… - Brain Structure and …, 2016 - Springer
The cannabinoid type 1 receptor (Cnr1, CB1R) mediates a plethora of physiological
functions in the central nervous system as a presynaptic modulator of neurotransmitter …
functions in the central nervous system as a presynaptic modulator of neurotransmitter …