Compared with traditional de novo drug discovery, drug repurposing has become an
attractive drug discovery strategy due to its low-cost and high efficiency. Through a …

Inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC) are
common diseases of the digestive system. Vitamin deficiencies and gut microbiota dysbiosis …

As potential candidates for treating ulcerative colitis (UC), polysaccharides have been
attracting extensive interest in recent years. Cordyceps sinensis (C. sinensis) is a kind of …

High‐fat diets (HFDs) can trigger lipid accumulation, insulin resistance, and inflammatory
responses in the body, causing glucose and lipid metabolism dysfunction. This study aimed …

Sorafenib is one of the options for advanced hepatocellular carcinoma treatment and has
been shown to extend median overall survival. However, sorafenib resistance often …

High-fat diets (HFD) could cause obesity, trigger lipid accumulation, and induce oxidative
stress and inflammation, leading to kidney damage. This study aimed to elucidate the …

The failure of and resistance to oxaliplatin (OXA)-based chemotherapies may lead to poor
prognosis in colorectal cancer (CRC) patients. It has been reported that orlistat (Orli) exhibits …

Obesity is characterized by the excessive accumulation of fat, which triggers a low-grade
chronic inflammatory process. Currently, the search for compounds with anti-obesogenic …

Lipid metabolism plays an important role in the occurrence and development of cancer, in
particular, digestive system tumors such as colon cancer. Here, we investigated the role of …

Obesity‐induced metabolic disorders can cause chronic inflammation in the whole body,
activating the nuclear factor kappa B (NF‐κB) pathway and inducing apoptosis. Therefore …