For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Autophagy, defined as a scavenging process of protein aggregates and damaged
organelles mediated by lysosomes, plays a significant role in the quality control of …

Targeted deletion of Raptor, a component of mechanistic target of rapamycin complex 1
(mTORC1), reveals an essential role for mTORC1 in initiation/maintenance of leukemia in a …

Inhibition of B-cell receptor (BCR) signaling pathways in chronic lymphocytic leukemia (CLL)
provides significant clinical benefit to patients, mainly by blocking adhesion of CLL cells in …

Aberrant activation of the phosphoinositide 3-kinase (PI3K) signaling network is a key event
in many human cancers and therefore enormous efforts have been made in the …

Purpose: B-cell receptor (BCR)–associated kinase inhibitors, such as ibrutinib, have
revolutionized the treatment of chronic lymphocytic leukemia (CLL). However, these agents …

Casein kinase 1δ/ε (CK1δ/ε) is a key component of noncanonical Wnt signaling pathways,
which were shown previously to drive pathogenesis of chronic lymphocytic leukemia (CLL) …

Optimal function of multiple intracellular signaling pathways is essential for normal
regulation of cellular transcription, translation, growth, proliferation, and survival …

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy with a mature phenotype. In
spite of its relatively indolent nature, no radical cure is as yet available. CLL is not …

Aberrant activation of oncogenic signaling pathways in tumors can promote resistance to the
antitumor immune response. However, single blockade of these pathways is usually …