The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …

The ribosome has recently transitioned from being viewed as a passive, indiscriminate
machine to a more dynamic macromolecular complex with specialized roles in the cell …

The genetic underpinnings and end-stage pathological hallmarks of neurodegenerative
diseases are increasingly well defined, but the cellular pathophysiology of disease initiation …

During the past decade, catheter ablation of atrial fibrillation (AF) has evolved rapidly from
an investigational procedure to its current status as a commonly performed ablation …

Background Atrial fibrillation (AF) represents an increasing public health challenge with
profound social and economic implications. Methods A comprehensive synthesis and review …

Atrial fibrillation (AF) is the most common arrhythmia with ever-increasing public health
impact. 1 Over 50 years of observation in the Framingham Heart Study (FHS), there is a 4 …

The eukaryotic cell is organized into membrane-covered compartments that are
characterized by specific sets of proteins and biochemically distinct cellular processes. The …

The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …

Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …