Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of
hematopoietic stem and progenitor cells (HSPCs) to blood cell production. The prevalence …

Chronologic age is the dominant risk factor for coronary artery disease but the features of
aging promoting coronary artery disease are poorly understood. Advances in human …

Clonal hematopoiesis (CH) is an age-related process whereby hematopoietic stem and
progenitor cells (HSPCs) acquire mutations that lead to a proliferative advantage and clonal …

Addressing the need for more equitable cardio-oncology care requires attention to existing
disparities in cardio-oncologic disease prevention and outcomes. This is particularly …

Clonal hematopoiesis of indeterminate potential (CHIP) is a common bone marrow
abnormality induced by age‐related DNA mutations, which give rise to proinflammatory …

BACKGROUND: Hypertension incidence increases with age and represents one of the most
prevalent risk factors for cardiovascular disease. Clonal events in the hematopoietic system …

Background Clonal hematopoiesis (CH) gives rise to mutated leukocyte clones that induce
cardiovascular inflammation and thereby impact the disease course in atherosclerosis and …

Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal
alterations (mCAs) of the autosomes, X, and Y chromosomes are aging-related somatic …

Megabase-scale mosaic chromosomal alterations (mCAs) in blood are prognostic markers
for a host of human diseases. Here, to gain a better understanding of mCA rates in …