[HTML][HTML] Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system
S Schuth, S Le Blanc, TG Krieger, J Jabs… - Journal of Experimental …, 2022 - Springer
Abstract Background Cancer-associated fibroblasts (CAFs) are considered to play a
fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and …
fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and …
[HTML][HTML] Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool
J Obreque, L Vergara-Gómez, N Venegas, H Weber… - Biological Research, 2023 - Springer
Abstract In December 2022 the US Food and Drug Administration (FDA) removed the
requirement that drugs in development must undergo animal testing before clinical …
requirement that drugs in development must undergo animal testing before clinical …
Evolving tumor characteristics and smart nanodrugs for tumor immunotherapy
W Sun, S Xie, SF Liu, X Hu, D Xing - International Journal of …, 2024 - Taylor & Francis
Typical physiological characteristics of tumors, such as weak acidity, low oxygen content,
and upregulation of certain enzymes in the tumor microenvironment (TME), provide survival …
and upregulation of certain enzymes in the tumor microenvironment (TME), provide survival …
[HTML][HTML] Cancer-associated fibroblasts are key determinants of cancer cell invasion in the earliest stage of colorectal cancer
H Dang, TJ Harryvan, CY Liao, EHJ Danen… - Cellular and Molecular …, 2023 - Elsevier
Background & Aims Improving clinical management of early stage colorectal cancers
(T1CRCs) requires a better understanding of their underlying biology. Accumulating …
(T1CRCs) requires a better understanding of their underlying biology. Accumulating …
[HTML][HTML] Validation of a novel EUS-FNB-derived organoid Co-culture system for drug screening in patients with pancreatic cancer
SE Grützmeier, B Kovacevic, P Vilmann, CV Rift… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic cancer is a devastating disease with a 5-year survival rate of
12%. Only about 20% of patients are candidates for curative surgery, while the majority …
12%. Only about 20% of patients are candidates for curative surgery, while the majority …
[HTML][HTML] Biomarker screen for efficacy of oncolytic virotherapy in patient-derived pancreatic cancer cultures
TE Schäfer, LI Knol, FV Haas, A Hartley… - …, 2024 - thelancet.com
Background Pancreatic ductal adenocarcinoma (PDAC) is a tumour entity with unmet
medical need. To assess the therapeutic potential of oncolytic virotherapy (OVT) against …
medical need. To assess the therapeutic potential of oncolytic virotherapy (OVT) against …
[HTML][HTML] Gastrointestinal cancer-associated fibroblasts expressing Junctional Adhesion Molecule-A are amenable to infection by oncolytic reovirus
TJ Harryvan, M Golo, N Dam… - Cancer Gene …, 2022 - nature.com
Gastrointestinal (GI) cancers are characterized by extensive tumor stroma that both
promotes tumor progression and acts as a physical barrier for adjacent tumor cells, limiting …
promotes tumor progression and acts as a physical barrier for adjacent tumor cells, limiting …
Preclinical evaluation of the gorilla‐derived HAdV‐B AdV‐lumc007 oncolytic adenovirus 'GoraVir'for the treatment of pancreatic ductal adenocarcinoma
STF Bots, TJ Harryvan, C Groeneveldt… - Molecular …, 2024 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy which shows
unparalleled therapeutic resistance due to its genetic and cellular heterogeneity, dense …
unparalleled therapeutic resistance due to its genetic and cellular heterogeneity, dense …
[HTML][HTML] Radiation response assessment of organoids derived from patients with pancreatic cancer
IWJM van Goor, L Raymakers, DSH Andel… - Clinical and translational …, 2024 - Elsevier
Background The effectiveness of radiotherapy for pancreatic cancer is debated. Patient-
derived organoids (PDOs) already mimicked clinical radiation response in other cancer …
derived organoids (PDOs) already mimicked clinical radiation response in other cancer …
[PDF][PDF] Preclinical evaluation of the gorilla-derived oncolytic adenovirus AdV-lumc007 “GoraVir” for the treatment of pancreatic ductal adenocarcinoma
STF Bots, T Harryvan, C Groeneveldt… - Mol …, 2022 - scholarlypublications …
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy which shows
unparalleled therapeutic resistance due to its genetic and cellular heterogeneity, dense …
unparalleled therapeutic resistance due to its genetic and cellular heterogeneity, dense …