The cell cycle checkpoint proteins ataxia-telangiectasia-mutated-and-Rad3-related kinase
(ATR) and its major downstream effector checkpoint kinase 1 (CHK1) prevent the entry of …

Mitosis is the process of cell division and is regulated by checkpoints in the cell cycle. G1-S,
S, and G2-M are the three main checkpoints that prevent initiation of the next phase of the …

Chronological aging is by far the strongest risk factor for age-related dementia and
Alzheimer's disease. Senescent cells accumulated in the aging and Alzheimer's disease …

Primary microcephaly (PM) refers to a congenitally small brain, resulting from insufficient
prenatal production of neurons, and serves as a model disease for brain volumic …

Simple Summary Platinum-resistant ovarian cancer (PROC) is a deadly cancer with a poor
prognosis. Some drugs targeting ATR have shown initial success in the treatment of PROC …

Radiotherapy (RT) remains a standard therapeutic modality for breast cancer patients.
However, intrinsic or acquired resistance limits the efficacy of RT. Here, we demonstrate that …

Inhibitors of checkpoint kinases ATR, Chk1, and Wee1 are currently being tested in
preclinical and clinical trials. Here, we review the basic principles behind the use of such …

DNA is constantly exposed to endogenous and exogenous mutagenic stimuli that are
capable of producing diverse lesions. In order to protect the integrity of the genetic material …

Homology directed repair is a critical process for maintaining the genome of mammalian
cells. While considered to be relatively error free, homologous recombination (HR) can lead …

Aim: To determine the prevalence of deleterious mutations in BRCA1 and BRCA2 and in 13
genes involved in homologous recombination repair (HRR), the prevalence of genomic loss …