Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Freestanding nonproteinogenic amino acids have long been recognized for their
antimetabolite properties and tendency to be uncovered to reactive functionalities by the …

For the past five decades, the need for new antibiotics has been met largely by
semisynthetic tailoring of natural product scaffolds discovered in the middle of the 20th …

Natural nonproteinogenic amino acids vastly outnumber the well-known 22 proteinogenic
amino acids. Such amino acids are generated in specialized metabolic pathways. In these …

Actinomycetes continue to be important sources for the discovery of secondary metabolites
for applications in human medicine, animal health, and crop protection. With the maturation …

Repetitive isolation of known compounds remains a major challenge in natural-product-
based drug discovery. LC-MS/MS-based molecular networking has become a highly …

Enzymes are nature's catalyst of choice for the highly selective and efficient coupling of
carbohydrates. Enzymatic sugar coupling is a competitive technology for industrial …

Catalytic asymmetric α-alkylation of carbonyl compounds represents a long-standing
challenge in synthetic organic chemistry. Herein, we advance a dual biocatalytic platform for …

Macrocyclization improves the pharmaceutical properties of peptides; however, regio-and
chemoselective intramolecular cyclizations remain challenging. Here we developed a …

Nonribosomal peptides are microbial secondary metabolites exhibiting a tremendous
structural diversity and a broad range of biological activities useful in the medical and agro …