[HTML][HTML] Microsatellite instability in Gastric Cancer: Between lights and shadows
Gastric cancer (GC) represents an important contributor to the global burden of cancer,
being one of the most common and deadly malignancies worldwide. According to TCGA and …
being one of the most common and deadly malignancies worldwide. According to TCGA and …
Predictive biomarkers in gastric cancer
C Röcken - Journal of cancer research and clinical oncology, 2023 - Springer
Predictive biomarkers are the mainstay of precision medicine. This review summarizes the
advancements in tissue-based diagnostic biomarkers for gastric cancer, which is considered …
advancements in tissue-based diagnostic biomarkers for gastric cancer, which is considered …
Mismatch repair and microsatellite instability testing for immune checkpoint inhibitor therapy: guideline from the College of American Pathologists in collaboration with …
AN Bartley, AM Mills, E Konnick… - … of pathology & …, 2022 - meridian.allenpress.com
Context.—The US Food and Drug Administration (FDA) approved immune checkpoint
inhibitor therapy for patients with advanced solid tumors that have DNA mismatch repair …
inhibitor therapy for patients with advanced solid tumors that have DNA mismatch repair …
Microsatellite instability in gastric cancer: molecular bases, clinical perspectives, and new treatment approaches
M Ratti, A Lampis, JC Hahne, R Passalacqua… - Cellular and Molecular …, 2018 - Springer
Gastric cancer is one of the most aggressive malignancies, with limited treatment options in
both locally advanced and metastatic setting, resulting in poor prognosis. Based on genomic …
both locally advanced and metastatic setting, resulting in poor prognosis. Based on genomic …
[HTML][HTML] PD-L1 is an independent prognostic predictor in gastric cancer of Western patients
Abstract Targeting the PD-1/PD-L1 immune checkpoint signaling is a novel promising
treatment strategy in several tumor entities, and it is suggested that PD-L1/PD-1 expression …
treatment strategy in several tumor entities, and it is suggested that PD-L1/PD-1 expression …
Microsatellite instability: from the implementation of the detection to a prognostic and predictive role in cancers
M Amato, R Franco, G Facchini, R Addeo… - International journal of …, 2022 - mdpi.com
Microsatellite instability (MSI) has been identified in several tumors arising from either
germline or somatic aberration. The presence of MSI in cancer predicts the sensitivity to …
germline or somatic aberration. The presence of MSI in cancer predicts the sensitivity to …
The novel negative checkpoint regulator VISTA is expressed in gastric carcinoma and associated with PD-L1/PD-1: A future perspective for a combined gastric cancer …
ABSTRACT A combined blockade of V-domain Ig suppressor of T-cell activation (VISTA)
and PD-1 is a promising new cancer treatment option, which was efficient in murine tumor …
and PD-1 is a promising new cancer treatment option, which was efficient in murine tumor …
Expression of the potential therapeutic target claudin-18.2 is frequently decreased in gastric cancer: results from a large Caucasian cohort study
M Dottermusch, S Krüger, HM Behrens, C Halske… - Virchows Archiv, 2019 - Springer
Gastric cancer (GC) is frequently diagnosed and treated in advanced tumour stages with
poor prognosis. Recent studies have identified isoform 2 of the tight junction protein claudin …
poor prognosis. Recent studies have identified isoform 2 of the tight junction protein claudin …
[HTML][HTML] Distinct molecular subtypes of gastric cancer: from Laurén to molecular pathology
M Cisło, AA Filip, GJA Offerhaus, B Ciseł… - Oncotarget, 2018 - ncbi.nlm.nih.gov
In Western countries the majority of gastric cancers (GC) are usually diagnosed in advanced
stages reporting a 5-year survival rate of only 26%. The Laurén classification of GC was …
stages reporting a 5-year survival rate of only 26%. The Laurén classification of GC was …