The role of peroxisome proliferator-activated receptors (PPAR) in immune responses
Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …
[HTML][HTML] PPARgamma in metabolism, immunity, and cancer: unified and diverse mechanisms of action
M Hernandez-Quiles, MF Broekema… - Frontiers in …, 2021 - frontiersin.org
The proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily,
is one of the most extensively studied ligand-inducible transcription factors. Since its …
is one of the most extensively studied ligand-inducible transcription factors. Since its …
[HTML][HTML] PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation
Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were
thought to serve as simple energy storing molecules. More recently it has been realized that …
thought to serve as simple energy storing molecules. More recently it has been realized that …
[HTML][HTML] PPARs as nuclear receptors for nutrient and energy metabolism
F Hong, S Pan, Y Guo, P Xu, Y Zhai - Molecules, 2019 - mdpi.com
It has been more than 36 years since peroxisome proliferator-activated receptors (PPARs)
were first recognized as enhancers of peroxisome proliferation. Consequently, many studies …
were first recognized as enhancers of peroxisome proliferation. Consequently, many studies …
The mechanisms of action of PPARs
J Berger, DE Moller - Annual review of medicine, 2002 - annualreviews.org
▪ Abstract The peroxisome proliferator-activated receptors (PPARs) are a group of three
nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes. PPARs …
nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes. PPARs …
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a member of the nuclear
receptor superfamily of ligand-dependent transcription factors that is predominantly …
receptor superfamily of ligand-dependent transcription factors that is predominantly …
Peroxisome proliferator-activated receptors: nuclear control of metabolism
B Desvergne, W Wahli - Endocrine reviews, 1999 - academic.oup.com
B. DNA binding properties C. PPAR ligand-binding properties D. Alternative pathways for
PPAR activation E. PPAR-mediated transactivation properties III. Physiological Aspects A …
PPAR activation E. PPAR-mediated transactivation properties III. Physiological Aspects A …
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
C Jiang, AT Ting, B Seed - Nature, 1998 - nature.com
The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a member of the nuclear
receptor family of transcription factors, a large and diverse group of proteins that mediate …
receptor family of transcription factors, a large and diverse group of proteins that mediate …
[HTML][HTML] PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
P Tontonoz, L Nagy, JGA Alvarez, VA Thomazy… - Cell, 1998 - cell.com
The formation of foam cells from macrophages in the arterial wall is characterized by
dramatic changes in lipid metabolism, including increased expression of scavenger …
dramatic changes in lipid metabolism, including increased expression of scavenger …
The PPARs: from orphan receptors to drug discovery
TM Willson, PJ Brown, DD Sternbach… - Journal of medicinal …, 2000 - ACS Publications
Dietary fat intake is an environmental factor that affects many aspects of human health. 1
Several lines of evidence suggest that common diseases of modern society are associated …
Several lines of evidence suggest that common diseases of modern society are associated …