The role of water compartments in the material properties of cortical bone

M Granke, MD Does, JS Nyman - Calcified tissue international, 2015 - Springer
Abstract Comprising~ 20% of the volume, water is a key determinant of the mechanical
behavior of cortical bone. It essentially exists in two general compartments: within pores and …

The mineral–collagen interface in bone

SR Stock - Calcified tissue international, 2015 - Springer
The interface between collagen and the mineral reinforcement phase, carbonated
hydroxyapatite (cAp), is essential for bone's remarkable functionality as a biological …

Nano-hydroxyapatite bone substitute functionalized with bone active molecules for enhanced cranial bone regeneration

AK Teotia, DB Raina, C Singh, N Sinha… - … applied materials & …, 2017 - ACS Publications
The aim of this study was to synthesize and characterize a nano-hydroxyapatite (nHAP) and
calcium sulfate bone substitute (NC) for cranioplasty. The NC was functionalized with low …

Bone hydration: How we can evaluate it, what can it tell us, and is it an effective therapeutic target?

RK Surowiec, MR Allen, JM Wallace - Bone reports, 2022 - Elsevier
Water constitutes roughly a quarter of the cortical bone by volume yet can greatly influence
mechanical properties and tissue quality. There is a growing appreciation for how water can …

The contribution of solid-state NMR spectroscopy to understanding biomineralization: atomic and molecular structure of bone

MJ Duer - Journal of Magnetic Resonance, 2015 - Elsevier
Solid-state NMR spectroscopy has had a major impact on our understanding of the structure
of mineralized tissues, in particular bone. Bone exemplifies the organic–inorganic composite …

Ex vivo exposure to calcitonin or raloxifene improves mechanical properties of diseased bone through non-cell mediated mechanisms

RK Surowiec, R Saldivar, RK Rai, CE Metzger… - Bone, 2023 - Elsevier
Raloxifene (RAL) reduces clinical fracture risk despite modest effects on bone mass and
density. This reduction in fracture risk may be due to improved material level-mechanical …

Nuclear magnetic resonance (NMR)‐based metabolomics for cancer research

R Ranjan, N Sinha - NMR in Biomedicine, 2019 - Wiley Online Library
Nuclear magnetic resonance (NMR) has emerged as an effective tool in various spheres of
biomedical research, amongst which metabolomics is an important method for the study of …

Behavior of water in collagen and hydroxyapatite sites of cortical bone: fracture, mechanical wear, and load bearing studies

F Gul-E-Noor, C Singh, A Papaioannou… - The Journal of …, 2015 - ACS Publications
The mechanical properties of cortical bone, which is largely composed of collagen,
hydroxyapatite, and water, are known to hinge on hydration. Recently, the characteristics of …

Solid-state NMR studies on the organic matrix of bone

HD Xue, Y Yin, T He, H Song, J Li, X Kong - Nano Research, 2023 - Springer
Bone is a hierarchical architecture that consists of both inorganic and organic components.
The organic components, including collagen and numerous non-collagenous biomolecules …

Gallstones: a worldwide multifaceted disease and its correlations with gallbladder carcinoma

RK Sharma, K Sonkar, N Sinha, P Rebala, AE Albani… - PLoS …, 2016 - journals.plos.org
Background Gallstones (GS) associated diseases are among the most recurrent and
frequent diseases delineated in India and United Arab Emirates. Several reports suggest …