Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups
Abstract Background Interleukin 6 (IL-6) signaling is being investigated as a therapeutic
target for atherosclerotic cardiovascular disease (CVD). While changes in circulating high …
target for atherosclerotic cardiovascular disease (CVD). While changes in circulating high …
Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis
Background Endometrial cancer is the most common gynaecological cancer in high-income
countries. Elevated body mass index (BMI) is an established modifiable risk factor for this …
countries. Elevated body mass index (BMI) is an established modifiable risk factor for this …
Additive Effects of Genetic Interleukin‐6 Signaling Downregulation and Low‐Density Lipoprotein Cholesterol Lowering on Cardiovascular Disease: A 2× 2 Factorial …
Background Although trials suggest that anti‐inflammatory approaches targeting interleukin
(IL)‐6 signaling can reduce cardiovascular risk, it remains unknown whether targeting IL‐6 …
(IL)‐6 signaling can reduce cardiovascular risk, it remains unknown whether targeting IL‐6 …
Genetically predicted circulating concentrations of micronutrients and risk of breast cancer: a Mendelian randomization study
The epidemiological literature reports inconsistent associations between consumption or
circulating concentrations of micronutrients and breast cancer risk. We investigated …
circulating concentrations of micronutrients and breast cancer risk. We investigated …