There is little doubt that the main component of the transmissible agent of spongiform
encephalopathies—the prion—is a conformational variant of the ubiquitous host protein …

Transmissible spongiform encephalopathies form a group of fatal neurodegenerative
disorders that have the unique property of being infectious, sporadic or genetic in origin …

Exposure of susceptible neuroblastoma N2a cells to mouse scrapie prions leads to infection,
as evidenced by the continued presence of the scrapie form of the prion protein (PrPSc) and …

Prions are usually quantified by bioassays based on intracerebral inoculation of mice that
are slow, imprecise, and costly. We have isolated neuroblastoma N2a sublines highly …

Prion diseases are transmissible neurodegenerative disorders affecting humans and
animals for which no therapeutic or prophylactic regimens exist. During the last three years …

Transmissible spongiform encephalopathies (TSEs) are fatal, untreatable
neurodegenerative diseases associated with the accumulation of a disease-specific form of …

Prions are thought to consist mainly or entirely of misfolded PrP, a constitutively expressed
host protein. Prions associated with the same PrP sequence may occur in the form of …

Based on in vitro observations in scrapie-infected neuroblastoma cells, quinacrine has
recently been proposed as a treatment for Creutzfeldt-Jakob disease (CJD), including a new …

Transmissible spongiform encephalopathies, or prion diseases, are fatal degenerative
disorders of the central nervous system that affect humans and animals. Prions are …

Over the last 30 years, many drugs have been tested both in cell culture and in vivo for their
ability to prevent the generation of prions and the development of transmissible spongiform …