Increasing evidence indicates that the tumor microenvironment has critical roles in all
aspects of cancer biology, including growth, angiogenesis, metastasis and progression …

FOXP3 is a transcription factor, which belongs to the family of FOX protein. FOXP3 was
initially discovered in regulatory T cells and supposed to play a significant role in the …

A hostile tumor microenvironment is one of the major obstacles for the efficacy of chimeric
antigen receptor modified T (CAR-T) cells, and combination treatment might be a potential …

Migration of cells toward chemical cues, or chemotaxis, is important for many biologic
processes such as immune defense, wound healing and cancer metastasis. Although …

FOXP3 functions not only as the master regulator in regulatory T cells, but also as an X-
linked tumor suppressor. The tumor-suppressive activity of FOXP3 has been observed in …

Multiplex immunofluorescence (mIF) allows simultaneous antibody-based detection and
quantification of the expression of up to six markers, plus a nuclear counterstain, on a single …

Breast cancer occurs in approximately 1 in 8 women and 1 in 37 women with breast cancer
succumbed to the disease. Over the past decades, new diagnostic tools and treatments …

Abstract Forkhead box P3 (FOXP3), an X-linked tumor suppressor gene, plays an important
role in breast cancer. However, the biological functions of FOXP3 in breast cancer …

With the intent to identify biomarkers in renal cell carcinoma (RCC) the functional status of T-
regulatory cells (Tregs) was investigated in primary RCC. Tregs were isolated from tumoral …

The metastasis of cancer is a complex and life-threatening process that is only partially
understood. Immune suppressive cells are recognized as important contributors to tumour …