Cancer chemopreventive agents are typically natural products or their synthetic analogs that
inhibit the transformation of normal cells to premalignant cells or the progression of …

For several millennia, the willow tree and salicin have been associated with salicylic acid,
the key precursor molecule that has contributed to the discovery of acetylsalicylic acid …

Evidence that curcumin may have anticancer activities has renewed interest in its potential
to prevent and treat disease. In this study, we show that curcumin-mediated rapid generation …

The biology of the mitochondrial electron transport chain is summarized. Our approach to
the mechanism of uncouplers, inhibitors, and toxins is based on electron transfer (ET) and …

The plant mitochondrial electron transport chain is branched such that electrons at ubiquinol
can be diverted to oxygen via the alternative oxidase (AOX). This pathway does not …

Aspirin and other nonsteroidal anti-inflammatory drugs inhibit cell proliferation and induce
apoptosis in various cancer cell lines, which is considered to be an important mechanism for …

Cancer chemopreventive agents block the transformation of normal cells and/or suppress
the promotion of premalignant cells to malignant cells. Certain agents may achieve these …

Alpha-pinene is a key compound of the essential oils extracted from many species of
coniferous trees. It is known for its biological activities. The aim of the present study was to …

Acadesine, 5-aminoimidazole-4-carboxamide (AICA) riboside, induced apoptosis in B-cell
chronic lymphocytic leukemia (B-CLL) cells in all samples tested (n= 70). The half-maximal …

Aspirin-induced apoptosis is one of the important mechanisms for its antitumour effect
against gastric cancer. We aimed at investigating the involvement of bcl-2 family members in …