Significant intra-and interindividual variability has been observed in response to use of
pharmacological agents in treatment of HIV infection. Treatment of HIV infection is limited by …

Liver disease in human immunodeficiency virus (HIV)-infected individuals encompasses the
spectrum from abnormal liver function tests, liver decompensation, with and without …

Objectives: Although several antiretroviral drugs, including the d-drugs stavudine (d4T) and
didanosine (ddI), may cause biomarker-defined hepatotoxicity, their association with …

While conventional parameters used to detect hepatotoxicity in drug safety assessment
studies are generally informative, the need remains for parameters that can detect the …

Introduction: The knowledge base of drug-induced liver injury (DILI) continues to grow each
year as additional drugs are identified as hepatotoxins. There is still a need to improve our …

If we could predict and prevent idiosyncratic drug reactions (IDRs) it would have a profound
effect on drug development and therapy. Given our present lack of mechanistic …

Khayelitsha is Cape Town's largest township, approximately 35km from the city centre. It was
originally developed as a dormitory town to house the increasing influx of African migrant …

Background: In Human Immunodeficiency Virus (HIV) infected patients on antiretroviral
treatment (ART), hepatotoxicity is life threatening. Its outcome may lead to liver failure and …

Background Prompt management of side effects is critical to supporting adherence to
antiretroviral (ARV) medication. Objective This study examines the impact of presenting side …

Background. Liver diseases are the leading causes of death in human immunodeficiency
virus (HIV)–positive persons since the widespread use of combination antiretroviral …