Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …

The placenta is the chief regulator of nutrient supply to the growing embryo during gestation.
As such, adequate placental function is instrumental for developmental progression …

The causes of preeclampsia remain one of the great medical mysteries of our time. This
syndrome is thought to occur in 2 stages with abnormal placentation leading to a maternal …

Hofbauer cells (HBCs) are a population of macrophages found in high abundance within the
stroma of the first-trimester human placenta. HBCs are the only fetal immune cell population …

Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …

Preeclampsia is a major complication of pregnancy manifested as hypertension and often
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …

Objective: To characterize the gut microbiota in patients with preeclampsia (PE) compared
with healthy controls. Methods: We analyzed and compared the microbiota communities in …

Deficiency in decidualization has been widely regarded as an important cause of
spontaneous abortion. Generalized decidualization also includes massive infiltration and …

A successful human pregnancy requires precisely timed adaptations by the maternal
immune system to support fetal growth while simultaneously protecting mother and fetus …