Targeting drugs to tumours using cell membrane-coated nanoparticles

RH Fang, W Gao, L Zhang - Nature Reviews Clinical Oncology, 2023 - nature.com
Traditional cancer therapeutics, such as chemotherapies, are often limited by their non-
specific nature, causing harm to non-malignant tissues. Over the past several decades …

The evolution of commercial drug delivery technologies

AM Vargason, AC Anselmo, S Mitragotri - Nature biomedical …, 2021 - nature.com
Drug delivery technologies have enabled the development of many pharmaceutical
products that improve patient health by enhancing the delivery of a therapeutic to its target …

Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape

Q Wu, L You, E Nepovimova, Z Heger, W Wu… - Journal of hematology & …, 2022 - Springer
Hypoxia, a common feature of the tumor microenvironment in various types of cancers,
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …

Nanotechnology for boosting cancer immunotherapy and remodeling tumor microenvironment: the horizons in cancer treatment

S Gao, X Yang, J Xu, N Qiu, G Zhai - ACS nano, 2021 - ACS Publications
Immunotherapy that harnesses the human immune system to fight cancer has received
widespread attention and become a mainstream strategy for cancer treatment. Cancer …

Natural killer cells: a promising immunotherapy for cancer

J Chu, F Gao, M Yan, S Zhao, Z Yan, B Shi… - Journal of translational …, 2022 - Springer
As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have
recently gained attention as an important type of innate immune regulatory cell. NK cells can …

Bioinspired and biomimetic delivery platforms for cancer vaccines

J Liu, SS Liew, J Wang, K Pu - Advanced Materials, 2022 - Wiley Online Library
Cancer vaccines aim at eliciting tumor‐specific responses for the immune system to identify
and eradicate malignant tumor cells while sparing the normal tissues. Furthermore, cancer …

[HTML][HTML] Proteogenomic characterization of endometrial carcinoma

Y Dou, EA Kawaler, DC Zhou, MA Gritsenko, C Huang… - Cell, 2020 - cell.com
We undertook a comprehensive proteogenomic characterization of 95 prospectively
collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This …

Engineered cell‐membrane‐coated nanoparticles directly present tumor antigens to promote anticancer immunity

Y Jiang, N Krishnan, J Zhou, S Chekuri… - Advanced …, 2020 - Wiley Online Library
The recent success of immunotherapies has highlighted the power of leveraging the
immune system in the fight against cancer. In order for most immune‐based therapies to …

Biomaterial-assisted targeted modulation of immune cells in cancer treatment

H Wang, DJ Mooney - Nature materials, 2018 - nature.com
The past decade has witnessed the accelerating development of immunotherapies for
cancer treatment. Immune checkpoint blockade therapies and chimeric antigen receptor …

CAR T-cell therapy: a new era in cancer immunotherapy

AN Miliotou, LC Papadopoulou - Current pharmaceutical …, 2018 - ingentaconnect.com
Background: Cancer is one of the leading causes of death worldwide. Over the years, a
number of conventional cytotoxic approaches for neoplastic diseases has been developed …