Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment

V Rajeev, YL Chai, L Poh, S Selvaraji, DY Fann… - Acta neuropathologica …, 2023 - Springer
Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related
to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically …

A brief overview of a mouse model of cerebral hypoperfusion by bilateral carotid artery stenosis

H Ishikawa, A Shindo, A Mizutani… - Journal of Cerebral …, 2023 - journals.sagepub.com
Vascular cognitive impairment (VCI) refers to all forms of cognitive disorder related to
cerebrovascular diseases, including vascular mild cognitive impairment, post-stroke …

Understanding the lived experiences of family caregivers of individuals with dementia in Soweto, a South African Township

A Mahomed, C Pretorius - Dementia, 2022 - journals.sagepub.com
This study was undertaken to understand South African family caregivers' lived experiences
of individuals living with dementia in a predominantly Black African township. A …

Human amnion epithelial cell therapy reduces hypertension-induced vascular stiffening and cognitive impairment

QN Dinh, C Lo, DW Zhang, V Tran… - Scientific Reports, 2024 - nature.com
Vascular inflammation and fibrosis are hallmarks of hypertension and contribute to the
development of cardiovascular disease and cognitive impairment. However, current anti …

Post-stroke cognitive impairment and brain hemorrhage are augmented in hypertensive mice

DE Wong Zhang, TA Gibson Hughes… - Journal of Cerebral …, 2024 - journals.sagepub.com
Hypertension is a major risk factor for both stroke and cognitive impairment, but it is unclear
whether it may specifically affect post-stroke cognitive impairment. We assessed the effect of …

Treadmill exercise during cerebral hypoperfusion has only limited effects on cognitive function in middle-aged subcortical ischemic vascular dementia mice

R Ohtomo, H Ishikawa, K Kinoshita… - Frontiers in Aging …, 2021 - frontiersin.org
Clinical and basic research suggests that exercise is a safe behavioral intervention and is
effective for improving cognitive function in cerebrovascular diseases, including subcortical …

Hypertension Promotes Neuroinflammation, Brain Injury and Cognitive Impairment

Q Dinh, A Vinh, C Lo, DW Zhang… - Authorea …, 2023 - advance.sagepub.com
Background and purpose: Hypertension increases the risk for cognitive impairment and
promotes vascular and renal inflammation. We tested if immune cell infiltration occurs in the …

[HTML][HTML] What we have learned to date from the omics approach to non-Alzheimer's dementias

M Demirci, OA Kadirhan - Journal of Integrative Neuroscience, 2022 - imrpress.com
Worldwide, more than 50 million people live with dementia, and due to the rapidly aging
population, dementia cases are expected to increase at least five times in 2050. 30%–40 …

Drug nanotargeting for treatment of neurodegeneration and aging

JS D'Arrigo - Aging Pathobiology and Therapeutics, 2021 - luolan-bio.com
Microvascular endothelial dysfunction precedes, often by decades, the cognitive decline
associated with Alzheimer's disease. Accordingly, cerebrovascular risk factors (eg …