Lipoxygenase metabolism: roles in tumor progression and survival

GP Pidgeon, J Lysaght, S Krishnamoorthy… - Cancer and Metastasis …, 2007 - Springer
The metabolism of arachidonic acid through lipoxygenase pathways leads to the generation
of various biologically active eicosanoids. The expression of these enzymes vary throughout …

Rational design of multi-stimuli-responsive nanoparticles for precise cancer therapy

X An, A Zhu, H Luo, H Ke, H Chen, Y Zhao - Acs Nano, 2016 - ACS Publications
Stimuli-responsive nanoparticles with target capacity are of great interest in drug delivery for
cancer therapy. However, the challenge is to achieve highly smart release with precise …

Single-cell enzyme concentrations, kinetics, and inhibition analysis using high-density hydrodynamic cell isolation arrays

D Di Carlo, N Aghdam, LP Lee - Analytical chemistry, 2006 - ACS Publications
High-quality single-cell data are required for a quantitative systems biology description of
cellular function. However, data of this type are difficult and time-consuming to collect using …

(−)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 …

M Shimizu, A Deguchi, JTE Lim, H Moriwaki… - Clinical cancer …, 2005 - AACR
Abstract Purpose:(−)-Epigallocatechin gallate (EGCG) inhibits activation of the epidermal
growth factor receptor (EGFR) and human epidermal growth factor receptor-2 (HER2) and …

Larrea tridentata (Creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid

S Arteaga, A Andrade-Cetto, R Cárdenas - Journal of ethnopharmacology, 2005 - Elsevier
Although controversial, Creosote bush, Larrea tridentata (Sesse and Moc. ex DC) Coville, is
used to treat a variety of illnesses including infertility, rheumatism, arthritis, diabetes …

Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines

T Hida, K Kozaki, H Muramatsu, A Masuda… - Clinical Cancer …, 2000 - AACR
In recent years, a combination of two demographic phenomena, an increase in the number
of older people in the population and an increase in the incidence of lung cancer with age …

Organoselenium compounds as potential therapeutic and chemopreventive agents: a review

M Soriano-Garcia - Current medicinal chemistry, 2004 - ingentaconnect.com
Selenium is an essential trace element. It is, however toxic at concentration little above
which is required for health. Selenium is incorporated into proteins as selenocysteine, the …

Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer

DJ Stewart - Critical reviews in oncology/hematology, 2010 - Elsevier
While chemotherapy provides useful palliation, advanced lung cancer remains incurable
since those tumors that are initially sensitive to therapy rapidly develop acquired resistance …

Cyclooxygenase-2 as a target for anticancer drug development

JB Méric, S Rottey, K Olaussen, JC Soria… - Critical reviews in …, 2006 - Elsevier
The two isoforms cyclooxygenase-1 and-2 catalyze the initial step in the formation of
prostaglandins in a variety of pathophysiological processes. More recently their role in …

[HTML][HTML] Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: an update

JM Lü, J Nurko, SM Weakley, J Jiang… - … medical journal of …, 2010 - ncbi.nlm.nih.gov
Creosote bush, Larrea tridentata, is known as chaparral or greasewood in the United States
and as gobernadora or hediondilla in Mexico. Nordihydroguaiaretic acid (NDGA), the main …