Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind
to specific molecules with high affinity, and offer a number of advantages relative to …

Dynamic DNA nanotechnology, a subfield of DNA nanotechnology, is concerned with the
study and application of nucleic acid strand-displacement reactions. Strand-displacement …

The quantum spin properties of nitrogen-vacancy defects in diamond enable diverse
applications in quantum computing and communications. However, fluorescent …

Three-dimensional cell and organoid cultures rely on the mechanical support of viscoelastic
matrices. However, commonly used matrix materials lack control over key cell-instructive …

We report DNA-and RNA-like systems built from eight nucleotide “letters”(hence the name
“hachimoji”) that form four orthogonal pairs. These synthetic systems meet the structural …

Transcription rates are regulated by the interactions between RNA polymerase, sigma factor,
and promoter DNA sequences in bacteria. However, it remains unclear how non-canonical …

A grand challenge in the fields of chemistry and materials science is the ability to construct f
the plac or a giv ement of en application. each component in or materials with absolute …

This review discusses one-dimensional supramolecular polymers that form in aqueous
media. First, naturally occurring supramolecular polymers are described, in particular …

INTRODUCTION Extensive tumor sequencing efforts have transformed the way in which
cancer driver genes are identified. Appropriate statistical modeling is crucial for …

Polymerase chain reaction (PCR) is a basic molecular biology technique with a multiplicity
of uses, including deoxyribonucleic acid cloning and sequencing, functional analysis of …