CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer
cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor …

High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte
trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high …

Secondary lymphoid organs are integral to initiation and execution of adaptive immune
responses. These organs provide a setting for interactions between antigen-specific …

Sjögren's syndrome (SS) is a prototype autoimmune disease characterized by oral and
ocular mucosal dryness following chronic inflammation of salivary and lachrymal glands …

Autoimmune disease, caused by unwanted immune responses to self-antigens, affects
millions of people each year and poses a great social and economic burden to individuals …

Objective Although Th17 cells have been increasingly recognised as an important effector in
various autoimmune diseases, their function in the pathogenesis of Sjögren's syndrome (SS) …

Objective Primary Sjögren's syndrome (SS) is a systemic autoimmune disease with
incompletely understood etiology. This study was undertaken to investigate the role of …

Lymphoid neogenesis is traditionally viewed as a pre‐programmed process that promotes
the formation of lymphoid organs during development. Here, the spatial organization of T …

Aging is a complex biological process in which many organs are pathologically affected. We
previously reported that aged C57BL/6J had increased lacrimal gland (LG) lymphoid …

Bruton's tyrosine kinase (BTK) is an intracellular signaling molecule first identified as the
molecule affected in X-linked agammaglobulinemia (XLA) patients, who almost completely …