The clinical management of tumour lysis syndrome in haematological malignancies
A Will, E Tholouli - British journal of haematology, 2011 - Wiley Online Library
Tumour lysis syndrome (TLS) is caused by the disintegration of malignant cells, usually
following the instigation of chemotherapy, although it may already be established at the time …
following the instigation of chemotherapy, although it may already be established at the time …
Engineered Escherichia coli Nissle 1917 with urate oxidase and an oxygen-recycling system for hyperuricemia treatment
R Zhao, Z Li, Y Sun, W Ge, M Wang, H Liu, L Xun… - Gut …, 2022 - Taylor & Francis
Hyperuricemia is the second most prevalent metabolic disease to human health after
diabetes. Only a few clinical drugs are available, and most of them have serious side effects …
diabetes. Only a few clinical drugs are available, and most of them have serious side effects …
Cloning, expression, and purification of recombinant uricase enzyme from Pseudomonas aeruginosa Ps43 using Escherichia coli
MI Shaaban, E Abdelmegeed, YM Ali - Journal of Microbiology and …, 2015 - koreascience.kr
Uricase is an important microbial enzyme that can be used in the clinical treatment of gout,
hyperuricemia, and tumor lysis syndrome. A total of 127 clinical isolates of Pseudomonas …
hyperuricemia, and tumor lysis syndrome. A total of 127 clinical isolates of Pseudomonas …
Determination of 8− hydroxy− 2ˊ− deoxyguanosine in urine with “linear” mode sparked graphite screen-printed electrodes
MG Trachioti, J Hrbac, MI Prodromidis - Electrochimica Acta, 2021 - Elsevier
The development of sensors for diagnostic purposes is of immense importance. Despite the
number of proposed sensors showing attractive detection capabilities, the widespread use …
number of proposed sensors showing attractive detection capabilities, the widespread use …
Rasburicase for the treatment of tumor lysis in hematological malignancies
G Malaguarnera, M Giordano… - Expert review of …, 2012 - Taylor & Francis
Tumor lysis syndrome (TLS) is a common oncologic emergency in patients with
hematological malignancies sensitive to cytotoxic treatment that present a high proliferative …
hematological malignancies sensitive to cytotoxic treatment that present a high proliferative …
Molecular Elucidation of a Urate Oxidase from Deinococcus radiodurans for Hyperuricemia and Gout Therapy
YC Chiu, TS Hsu, CY Huang, CH Hsu - International Journal of Molecular …, 2021 - mdpi.com
Urate oxidase initiates the uric acid degradation pathways and is extensively used for
protein drug development for gout therapy and serum uric acid diagnosis. We first present …
protein drug development for gout therapy and serum uric acid diagnosis. We first present …
Directed evolution to improve the catalytic efficiency of urate oxidase from Bacillus subtilis
Urate oxidase is a key enzyme in purine metabolism and catalyzes the oxidation of uric acid
to allantoin. It is used to treat hyperuricemia and gout, and also in a diagnostic kit. In this …
to allantoin. It is used to treat hyperuricemia and gout, and also in a diagnostic kit. In this …
Crystal structure of Bacillus fastidious uricase reveals an unexpected folding of the C-terminus residues crucial for thermostability under physiological conditions
J Feng, L Wang, H Liu, X Yang, L Liu, Y Xie… - Applied microbiology …, 2015 - Springer
Bacillus fastidious uricase (BF uricase) containing 322 amino acid residues exhibited high
stability under physiological conditions. Its crystal structure was solved to 1.4-Å resolution …
stability under physiological conditions. Its crystal structure was solved to 1.4-Å resolution …
Flow-through electrochemical biosensor with a replaceable enzyme reactor and screen-printed electrode for the determination of uric acid and tyrosine
A flow-through biosensor has been developed and manufactured by 3D printing from poly
(lactic acid). Uricase or tyrosinase were immobilized on the inner walls of the reactor cell …
(lactic acid). Uricase or tyrosinase were immobilized on the inner walls of the reactor cell …
High-yield expression, purification, characterization, and structure determination of tag-free Candida utilis uricase
X Liu, M Wen, J Li, F Zhai, J Ruan, L Zhang… - Applied microbiology and …, 2011 - Springer
We report the successful high-yield expression of Candida utilis uricase in Escherichia coli
and the establishment of an efficient three-step protein purification protocol. The purity of the …
and the establishment of an efficient three-step protein purification protocol. The purity of the …