Subarachnoid hemorrhage (SAH) can lead to devastating neurological outcomes, and there
are few pharmacologic treatments available for treating this condition. Both animal and …

BACKGROUND: Delayed vasospasm is the leading cause of morbidity and mortality after
aneurysmal subarachnoid hemorrhage (aSAH). This phenomenon was first described more …

Aneurysmal subarachnoid hemorrhage (aSAH) remains a leading cause of morbidity and
mortality in patients who survive the initial ictus, primarily as a result of the development of …

Aneurysmal subarachnoid hemorrhage (aSAH) represents only a small portion of all strokes,
but accounts for almost half of the deaths caused by stroke worldwide. Neurosurgical …

Appropriate vascular function is essential for the maintenance of central nervous system
homeostasis and is achieved through virtue of the blood-brain barrier; a specialized …

Cerebral vasospasm (CVS) is a potentially lethal complication of aneurysmal subarachnoid
hemorrhage (aSAH). Recently, the symptomatic presentation of CVS has been termed …

METHODS: Wild-type Hp 1-1 C57Bl/6J mice (n= 45) and genetically modified Hp 2-2
C57Bl/6J mice (n= 45), underwent injection of either autologous blood or normal saline into …

A matricellular protein tenascin-C (TNC) has been suggested to play a role in the
pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH), but the direct …

Objectives: To investigate the release of proinflammatory damage-associated molecular
pattern molecule “high-mobility group box-1” in the serum of patients after aneurysmal …

Survivors of cerebral aneurysm rupture are at risk for significant morbidity and neurological
deficits. Much of this is related to the effects of blood in the subarachnoid space which …