A comparison of the International Consensus and 5th World Health Organization classifications of mature B-cell lymphomas
Several editions of the World Health Organization (WHO) classifications of lympho-
hemopoietic neoplasms in 2001, 2008 and 2017 served as the international standard for …
hemopoietic neoplasms in 2001, 2008 and 2017 served as the international standard for …
Diagnosis and classification of hematologic malignancies on the basis of genetics
Genomic analysis has greatly influenced the diagnosis and clinical management of patients
affected by diverse forms of hematologic malignancies. Here, we review how genetic …
affected by diverse forms of hematologic malignancies. Here, we review how genetic …
The international consensus classification of mature lymphoid neoplasms: a report from the clinical advisory committee
Since the publication of the Revised European-American Classification of Lymphoid
Neoplasms in 1994, subsequent updates of the classification of lymphoid neoplasms have …
Neoplasms in 1994, subsequent updates of the classification of lymphoid neoplasms have …
Ibrutinib in previously treated Waldenström's macroglobulinemia
SP Treon, CK Tripsas, K Meid, D Warren… - … England Journal of …, 2015 - Mass Medical Soc
Background MYD88 L265P and CXCR4WHIM mutations are highly prevalent in
Waldenström's macroglobulinemia. MYD88L265P triggers tumor-cell growth through …
Waldenström's macroglobulinemia. MYD88L265P triggers tumor-cell growth through …
The genomic landscape of Waldenström macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic …
ZR Hunter, L Xu, G Yang, Y Zhou, X Liu… - Blood, The Journal …, 2014 - ashpublications.org
The genetic basis for Waldenström macroglobulinemia (WM) remains to be clarified.
Although 6q losses are commonly present, recurring gene losses in this region remain to be …
Although 6q losses are commonly present, recurring gene losses in this region remain to be …
Somatic mutations in MYD88 and CXCR4 are determinants of clinical presentation and overall survival in Waldenström macroglobulinemia
SP Treon, Y Cao, L Xu, G Yang, X Liu… - Blood, The Journal of …, 2014 - ashpublications.org
Whole genome sequencing has revealed activating somatic mutations in MYD88 (L265P)
and CXCR4 in Waldenström macroglobulinemia (WM). CXCR4 somatic mutations in WM …
and CXCR4 in Waldenström macroglobulinemia (WM). CXCR4 somatic mutations in WM …
Genomic landscape of Waldenström macroglobulinemia and its impact on treatment strategies
SP Treon, L Xu, ML Guerrera, C Jimenez… - Journal of Clinical …, 2020 - ascopubs.org
Next-generation sequencing has revealed recurring somatic mutations in Waldenström
macroglobulinemia (WM), including MYD88 (95%-97%), CXCR4 (30%-40%), ARID1A …
macroglobulinemia (WM), including MYD88 (95%-97%), CXCR4 (30%-40%), ARID1A …
CXCR4 in Waldenström's Macroglobulinema: chances and challenges
It is one of the major aims in cancer research to improve our understanding of the underlying
mechanisms which initiate and maintain tumor growth and to translate these findings into …
mechanisms which initiate and maintain tumor growth and to translate these findings into …
The WHIM-like CXCR4S338X somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's …
CXCR4 WHIM somatic mutations are common Waldenstrom's Macroglobulinemia (WM), and
are associated with clinical resistance to ibrutinib. We engineered WM cells to express the …
are associated with clinical resistance to ibrutinib. We engineered WM cells to express the …
Acquired mutations associated with ibrutinib resistance in Waldenström macroglobulinemia
L Xu, N Tsakmaklis, G Yang, JG Chen… - Blood, The Journal …, 2017 - ashpublications.org
Ibrutinib produces high response rates and durable remissions in Waldenström
macroglobulinemia (WM) that are impacted by MYD88 and CXCR4WHIM mutations …
macroglobulinemia (WM) that are impacted by MYD88 and CXCR4WHIM mutations …