Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

Organoids, intricate three-dimensional tissue assemblies derived from either pluripotent or
adult stem cells cultured under laboratory conditions, emerge as a captivating model and …

Alginate (ALG), a polysaccharide derived from brown seaweed, has been extensively
investigated as a biomaterial not only in tissue engineering but also for numerous …

The extracellular matrix (ECM) is pivotal in modulating tumor progression. Besides
chemically stimulating tumor cells, it also offers physical support that orchestrates the …

Cells sense and respond to the physical properties of their environment through receptor-
mediated signaling, a process known as mechanotransduction, which can modulate critical …

Biomaterials for tissue scaffolds are key components in modern tissue engineering and
regenerative medicine. Targeted reconstructive therapies require a proper choice of …

Metastatic cancers are chemoresistant, involving complex interplay between disseminated
cancer cell aggregates and the distant organ microenvironment (extracellular matrix and …

In recent years, hydrogel-based three-dimensional tumor models have become increasingly
mainstream for cancer research. Hydrogels enable recapitulation of biochemical and …

Years of important research has revealed that cells heavily invest in regulating their size.
Nevertheless, it has remained unclear why accurate size control is so important. Our recent …

Breast cancer (BC) metastasis is an enormous challenge targeting BC therapy. The
extracellular matrix (ECM), the principal component of the BC metastasis niche, is the pivotal …