Background Oral lichen planus (OLP) is a local autoimmune disease induced by T-cell
dysfunction that frequently affects middle-aged or elderly people, with a higher prevalence in …

Autophagy is an evolutionarily conserved catabolic process that is induced in response to
various stress factors in order to protect cells and maintain cellular homeostasis by …

Highlights•Organisms are constantly exposed to environmental changes.•Environemental
cues alter chromatin organization at multiple levels.•Environment-driven 3D genome …

How cells adapt their gene expression to nutritional changes remains poorly understood.
Histone H3T11 is phosphorylated by pyruvate kinase to repress gene transcription. Here, we …

Chemoresistance remains a formidable challenge in pancreatic ductal adenocarcinoma
(PDAC) treatment, necessitating a comprehensive exploration of underlying molecular …

Autophagy is a pivotal regulatory and catabolic process, induced under various stressful
conditions, including hypoxia. However, little is known about alternative splicing of …

Epigenetic dysregulation that leads to alterations in gene expression and is suggested to be
one of the key pathophysiological factors of Parkinson's disease (PD). Here, we found that α …

Over the last decade, the functions of PHD finger protein 20 (PHF20) in several signaling
processes have been studied, including those of protein kinase B (PKB)-mediated …

Pemphigus foliaceus (PF) is an autoimmune skin blistering disease characterized by
antidesmoglein-1 IgG production, with an endemic form (EPF) in Brazil. Genetic and …

Background and Objective Periodontitis is an inflammatory disease that eventually destroys
tooth-supporting tissue. Yunnan Baiyao (YNBY), a traditional Chinese medicine compound …