Morphea, also known as localized scleroderma, is a chronic inflammatory connective tissue
disorder with variable clinical presentations, that affects both adults and children. It is …

Cytokines are small secreted proteins that have specific effects on cellular interactions and
are crucial for functioning of the immune system. Cytokines are involved in almost all …

Background Molecularly targeted therapies, such as monoclonal antibodies (mAbs) and
Janus Kinase inhibitors (JAKis), have emerged as essential tools in the treatment of …

To determine the effects of Tacrolimus (FK506) on Treg cells and subpopulations in SSc
patients and assess the ability of FK506 to modify the immune imbalance of Treg/Th17 cells …

Background To date, there are no accepted outcome measures to monitor morphea, and
consensus on specific monitoring criteria for morphea remains elusive. A few studies have …

Orbit, Anterior View. Shown in this illustration are the supraorbital notch, ethmoidal foramina,
optic foramen, superior orbital fissure (hourglass configuration), greater wing of the …

Juvenile localised scleroderma (JLS) is a condition that results in inflammation and fibrosis
of the skin in children and young people. Systemic treatment with immunomodulation is most …

Oral submucous fibrosis (OSMF) is a chronic, progressive, insidious premalignant disease
with multifactorial etiology affecting any part of the oral cavity and sometimes the pharynx by …

Pediatric dermatoses constitute an array of varied diseases, a few of which may require long-
term treatment with immunosuppressants in the form of corticosteroids (CS) and steroid …

Fundamentos: Terapias de alvo molecular, como anticorpos monoclonais (mAbs) e
inibidores de Janus Quinase (JAKis), surgiram como ferramentas essenciais para o …