Fluorine in anti-HIV drugs approved by FDA from 1981 to 2023
S Han, Y Lu - European Journal of Medicinal Chemistry, 2023 - Elsevier
Human immunodeficiency virus (HIV) is the etiological agent of acquired immunodeficiency
syndrome (AIDS). Nowadays, FDA has approved over thirty antiretroviral drugs grouped in …
syndrome (AIDS). Nowadays, FDA has approved over thirty antiretroviral drugs grouped in …
Structural biology of HIV integrase strand transfer inhibitors
Integrase (IN) strand transfer inhibitors (INSTIs) are recent compounds in the antiretroviral
arsenal used against HIV. INSTIs work by blocking retroviral integration; an essential step in …
arsenal used against HIV. INSTIs work by blocking retroviral integration; an essential step in …
Longitudinal trends in causes of death among adults with HIV on antiretroviral therapy in Europe and North America from 1996 to 2020: a collaboration of cohort …
Background Mortality rates among people with HIV have fallen since 1996 following the
widespread availability of effective antiretroviral therapy (ART). Patterns of cause-specific …
widespread availability of effective antiretroviral therapy (ART). Patterns of cause-specific …
Associations of modern initial antiretroviral drug regimens with all-cause mortality in adults with HIV in Europe and North America: a cohort study
Background Over the past decade, antiretroviral therapy (ART) regimens that include
integrase strand inhibitors (INSTIs) have become the most commonly used for people with …
integrase strand inhibitors (INSTIs) have become the most commonly used for people with …
Outcomes after switching to BIC/FTC/TAF in patients with virological failure to protease inhibitors or non-nucleoside reverse transcriptase inhibitors: a real-world cohort …
HM Chang, PY Chou, CH Chou… - Infection and Drug …, 2021 - Taylor & Francis
Purpose This study evaluated the real-world tolerability and treatment effectiveness of
BIC/FTC/TAF in treatment-experienced patients living with HIV-1 in Taiwan, especially in …
BIC/FTC/TAF in treatment-experienced patients living with HIV-1 in Taiwan, especially in …
Going beyond integration: The emerging role of HIV-1 integrase in virion morphogenesis
JL Elliott, SB Kutluay - Viruses, 2020 - mdpi.com
The HIV-1 integrase enzyme (IN) plays a critical role in the viral life cycle by integrating the
reverse-transcribed viral DNA into the host chromosome. This function of IN has been well …
reverse-transcribed viral DNA into the host chromosome. This function of IN has been well …
Use of integrase inhibitors in HIV-associated tuberculosis in high-burden settings: implementation challenges and research gaps
People living with HIV have a higher risk of developing tuberculosis, and tuberculosis is one
of the leading causes of death among people living with HIV globally. Treating HIV and …
of the leading causes of death among people living with HIV globally. Treating HIV and …
Evaluation of integrase resistance in individuals who failed a regimen containing dolutegravir in French and Italian clinical settings
Background This work aims to evaluate integrase resistance and its predictors in HIV-1
infected combined antiretroviral therapy (cART) experienced individuals failing a …
infected combined antiretroviral therapy (cART) experienced individuals failing a …
Impact of Integrase Sequences from HIV-1 Subtypes A6/A1 on the In Vitro Potency of Cabotegravir or Rilpivirine
JL Jeffrey, M St. Clair, P Wang, C Wang… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
The FLAIR study demonstrated noninferiority of monthly long-acting cabotegravir+ rilpivirine
versus daily oral dolutegravir/abacavir/lamivudine for maintaining virologic suppression …
versus daily oral dolutegravir/abacavir/lamivudine for maintaining virologic suppression …
Genetic features of HIV-1 integrase sub-subtype A6 predominant in Russia and predicted susceptibility to INSTIs
A Kirichenko, I Lapovok, P Baryshev… - Viruses, 2020 - mdpi.com
The increasing use of the integrase strand transfer inhibitor (INSTI) class for the treatment of
HIV-infection has pointed to the importance of analyzing the features of HIV-1 subtypes for …
HIV-infection has pointed to the importance of analyzing the features of HIV-1 subtypes for …