An altered pattern of epigenetic modifications is central to many common human diseases,
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …

Epigenetic mechanisms such as DNA methylation and modifications to histone proteins
regulate high-order DNA structure and gene expression. Aberrant epigenetic mechanisms …

Many genes associated with CpG islands undergo de novo methylation in cancer. Studies
have suggested that the pattern of this modification may be partially determined by an …

Purpose Non–small-cell lung cancer (NSCLC) is a tumor in which only small improvements
in clinical outcome have been achieved. The issue is critical for stage I patients for whom …

We have developed a high-throughput method for analyzing the methylation status of
hundreds of preselected genes simultaneously and have applied it to the discovery of …

The field of cancer epigenetics is evolving rapidly on several fronts. Advances in our
understanding of chromatin structure, histone modification, transcriptional activity and DNA …

Neuroblastoma (NB) is a pediatric cancer of the sympathetic nervous system and one of the
most common solid tumors in infancy. Amplification of MYCN, copy number alterations …

Background Promoter hypermethylation coupled with loss of heterozygosity at the same
locus results in loss of gene function in many tumor cells. The “rules” governing which genes …

The presence of common genomic deletions in the 19q13 chromosomal region in
neuroblastomas and gliomas strongly suggests the presence of a putative tumor suppressor …

Alterations in modifications of histones have been linked to deregulated expression of many
genes with important roles in cancer development and progression. The effects of these …