[HTML][HTML] Ischemia/reperfusion injury revisited: an overview of the latest pharmacological strategies
ROS Soares, DM Losada, MC Jordani, P Évora… - International journal of …, 2019 - mdpi.com
Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous
concern in every transplantation proceeding, from whole organs to modest grafts. Given its …
concern in every transplantation proceeding, from whole organs to modest grafts. Given its …
[HTML][HTML] PM2. 5-induced ADRB2 hypermethylation contributed to cardiac dysfunction through cardiomyocytes apoptosis via PI3K/Akt pathway
X Yang, T Zhao, L Feng, Y Shi, J Jiang, S Liang… - Environment …, 2019 - Elsevier
Background Long-term exposure to fine particulate matter (PM 2.5) can causally contribute
to progression of atherosclerosis, risk of ischemic heart disease and death, but the …
to progression of atherosclerosis, risk of ischemic heart disease and death, but the …
Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation
PY Sato, JK Chuprun, LA Grisanti, MC Woodall… - Science …, 2018 - science.org
Increased abundance of GRK2 [G protein–coupled receptor (GPCR) kinase 2] is associated
with poor cardiac function in heart failure patients. In animal models, GRK2 contributes to the …
with poor cardiac function in heart failure patients. In animal models, GRK2 contributes to the …
[HTML][HTML] Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
J Song, M Li, C Chen, J Zhou, L Wang, Y Yan… - Cellular & Molecular …, 2023 - Springer
Background Acute respiratory distress syndrome (ARDS) is a disease with high mortality
and morbidity. Regulator of G protein signaling protein 6 (RGS6), identified as a tumor …
and morbidity. Regulator of G protein signaling protein 6 (RGS6), identified as a tumor …
[HTML][HTML] Nuclear import of Mas-related G protein-coupled receptor member D induces pathological cardiac remodeling
K Zhao, D Hua, C Yang, X Wu, Y Mao, Y Sheng… - Cell Communication and …, 2023 - Springer
Alamandine (Ala), a ligand of Mas-related G protein-coupled receptor, member D (MrgD),
alleviates angiotensin II (AngII)-induced cardiac hypertrophy. However, the specific …
alleviates angiotensin II (AngII)-induced cardiac hypertrophy. However, the specific …
Protein profiling of RGS6, a pleiotropic gene implicated in numerous neuropsychiatric disorders, reveals multi-isoformic expression and a novel brain-specific isoform
KE Ahlers-Dannen, J Yang, MM Spicer, B Maity… - Eneuro, 2022 - eneuro.org
A metanalysis identified regulator of G-protein signaling 6 (RGS6) as one of 23 loci with
pleiotropic effects on four or more human psychiatric disorders. This finding is significant as …
pleiotropic effects on four or more human psychiatric disorders. This finding is significant as …
[HTML][HTML] Biomarker discovery in attention deficit hyperactivity disorder: RNA sequencing of whole blood in discordant twin and case-controlled cohorts
TA McCaffrey, G St. Laurent, D Shtokalo… - BMC medical …, 2020 - Springer
Background A variety of DNA-based methods have been applied to identify genetic markers
of attention deficit hyperactivity disorder (ADHD), but the connection to RNA-based gene …
of attention deficit hyperactivity disorder (ADHD), but the connection to RNA-based gene …
[HTML][HTML] Methamphetamine-induced changes in myocardial gene transcription are sex-dependent
H Chavva, DA Brazeau, J Denvir, DA Primerano, J Fan… - BMC genomics, 2021 - Springer
Background Prior work demonstrated that female rats (but not their male littermates)
exposed to methamphetamine become hypersensitive to myocardial ischemic injury …
exposed to methamphetamine become hypersensitive to myocardial ischemic injury …
[HTML][HTML] Cardiovascular Events with the Use of Long-Acting Muscarinic Receptor Antagonists: An Analysis of the FAERS Database 2020–2023
Purpose This study aimed to examine reports of cardiovascular adverse events (CV AEs)
observed in the real-world during treatment with aclidinium, tiotropium, glycopyrronium, and …
observed in the real-world during treatment with aclidinium, tiotropium, glycopyrronium, and …
Regulator of G Protein Signaling 6 Facilities Cardiac Hypertrophy by Activating Apoptosis Signal–Regulating Kinase 1–P38/c‐JUN N‐Terminal Kinase 1/2 Signaling
Z Huang, J Shu, W Jiang, M Jiang, Y Lu… - Journal of the …, 2018 - Am Heart Assoc
Background Regulator of G protein signaling 6 (RGS 6) is an important member of the RGS
family and produces pleiotropic regulatory effects on cardiac pathophysiology. However, the …
family and produces pleiotropic regulatory effects on cardiac pathophysiology. However, the …