Choline metabolism-based molecular diagnosis of cancer: an update
Abnormal choline metabolism continues to be identified in multiple cancers. Molecular
causes of abnormal choline metabolism are changes in choline kinase-α, ethanolamine …
causes of abnormal choline metabolism are changes in choline kinase-α, ethanolamine …
Methods to Increase the Metabolic Stability of 18F-Radiotracers
M Kuchar, C Mamat - Molecules, 2015 - mdpi.com
The majority of pharmaceuticals and other organic compounds incorporating radiotracers
that are considered foreign to the body undergo metabolic changes in vivo. Metabolic …
that are considered foreign to the body undergo metabolic changes in vivo. Metabolic …
MFSD7c functions as a transporter of choline at the blood–brain barrier
Mutations in the orphan transporter MFSD7c (also known as Flvcr2), are linked to Fowler
syndrome. Here, we used Mfsd7c knockout (Mfsd7c–/–) mice and cell-based assays to …
syndrome. Here, we used Mfsd7c knockout (Mfsd7c–/–) mice and cell-based assays to …
Positron emission tomography imaging of tumor cell metabolism and application to therapy response monitoring
A Challapalli, EO Aboagye - Frontiers in oncology, 2016 - frontiersin.org
Cancer cells do reprogram their energy metabolism to enable several functions, such as
generation of biomass including membrane biosynthesis, and overcoming bioenergetic and …
generation of biomass including membrane biosynthesis, and overcoming bioenergetic and …
Metabolomics approaches in pancreatic adenocarcinoma: tumor metabolism profiling predicts clinical outcome of patients
Abstract Background Pancreatic adenocarcinomas (PAs) have very poor prognoses even
when surgery is possible. Currently, there are no tissular biomarkers to predict long-term …
when surgery is possible. Currently, there are no tissular biomarkers to predict long-term …
Imaging tumor metabolism using positron emission tomography
Positron emission tomography (PET) is an extraordinarily sensitive clinical imaging modality
for interrogating tumor metabolism. Radiolabeled PET substrates can be traced at …
for interrogating tumor metabolism. Radiolabeled PET substrates can be traced at …
Metabolic imaging of pancreatic ductal adenocarcinoma detects altered choline metabolism
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal disease
that develops relatively symptom-free and is therefore advanced at the time of diagnosis …
that develops relatively symptom-free and is therefore advanced at the time of diagnosis …
Clinical translation of a click-labeled 18F-octreotate radioligand for imaging neuroendocrine tumors
SR Dubash, N Keat, P Mapelli, F Twyman… - Journal of Nuclear …, 2016 - Soc Nuclear Med
We conducted the first-in-human study of 18F-fluoroethyl triazole [Tyr3] octreotate (18F-FET-
βAG-TOCA) in patients with neuroendocrine tumors (NETs) to evaluate biodistribution …
βAG-TOCA) in patients with neuroendocrine tumors (NETs) to evaluate biodistribution …
The Effect of Deuteration on the Keto–enol Equilibrium and Photostability of the Sunscreen agent Avobenzone
The remarkable properties of deuterium have led to many exciting and favourable results in
enhancing material properties, for applications in the physical, medical, and biological …
enhancing material properties, for applications in the physical, medical, and biological …
[HTML][HTML] Near infrared fluorescent imaging of choline kinase alpha expression and inhibition in breast tumors
Choline kinase alpha (ChoKα) overexpression is associated with an aggressive tumor
phenotype. ChoKα inhibitors induce apoptosis in tumors, however validation of their …
phenotype. ChoKα inhibitors induce apoptosis in tumors, however validation of their …