The properties of granular materials depend strongly on the shapes of their individual
constituent particles or granules. Nonetheless, incorporating the effects of non-spherical or …

Background/Objectives: Numerical simulation plays an important role in pharmaceutical
preparation recently. Mechanistic models, as a type of numerical model, are widely used in …

The magnitude of the frictional forces during the ejection of porous pharmaceutical tablets
plays an important role in determining the occurrence of tabletting defects. Here, we perform …

Since famotidine (FA) is prescribed for gastrointestinal diseases orodispersible tablets could
contribute to patients' compliance. Its bitter taste and poor compressibility pose formulation …

Discrete element method simulations are conducted to probe the various regimes of
postimpact behavior of particles with solid surfaces. The impacting particles are described …

A set of numerical methods is described that allows predictive finite element method (FEM)
simulations of the compaction of multi-component pharmaceutical powder formulations …

Introduction Mini-tablets are considered a promising solid dosage form in the
pharmaceutical industry due to advantages such as dosing accuracy, efficiency as a drug …

Particulate processes are the basis of the production of solid dosage forms of medical and
nutritional therapeutics. The expansion of solid dose pharmaceutical manufacturing is …

Granular materials are ubiquitous in nature and industry alike, ranging from assemblies of
large rocks to the finest of powders. Nonetheless, compared to fluids and solids, our …

Despite widespread industrial reliance on powder compaction in manufacturing, a complete
understanding of the underlying physical mechanisms that lead to pore structure …