p63: a crucial player in epithelial stemness regulation
Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …
How important is EMT for cancer metastasis?
T Celià-Terrassa, Y Kang - PLoS biology, 2024 - journals.plos.org
Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity
initially reported in embryonic development, has been increasingly recognized for its …
initially reported in embryonic development, has been increasingly recognized for its …
Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression
L Chen, S Zhu, T Liu, X Zhao, T Xiang, X Hu… - … and Targeted Therapy, 2023 - nature.com
Epithelial-mesenchymal transition (EMT) and proliferation play important roles in epithelial
cancer formation and progression, but what molecules and how they trigger EMT is largely …
cancer formation and progression, but what molecules and how they trigger EMT is largely …
Cell-intrinsic and microenvironmental determinants of metastatic colonization
AW Lambert, Y Zhang, RA Weinberg - Nature Cell Biology, 2024 - nature.com
Cancer metastasis is a biologically complex process that remains a major challenge in the
oncology clinic, accounting for nearly all of the mortality associated with malignant …
oncology clinic, accounting for nearly all of the mortality associated with malignant …
A systems-level analysis of the mutually antagonistic roles of RKIP and BACH1 in dynamics of cancer cell plasticity
Epithelial–mesenchymal transition (EMT) is an important axis of phenotypic plasticity—a
hallmark of cancer metastasis. Raf kinase-B inhibitor protein (RKIP) and BTB and CNC …
hallmark of cancer metastasis. Raf kinase-B inhibitor protein (RKIP) and BTB and CNC …
ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness
E Vasilaki, Y Bai, MM Ali, A Sundqvist… - Cell Communication and …, 2024 - Springer
Background p63 is a transcription factor with intrinsic pioneer factor activity and pleiotropic
functions. Transforming growth factor β (TGFβ) signaling via activation and cooperative …
functions. Transforming growth factor β (TGFβ) signaling via activation and cooperative …
[HTML][HTML] MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells
Activation of the MUC1-C protein promotes lineage plasticity, epigenetic reprogramming,
and the cancer stem cell (CSC) state. The present studies performed on enriched …
and the cancer stem cell (CSC) state. The present studies performed on enriched …
Redox signalling regulates breast cancer metastasis via phenotypic and metabolic reprogramming due to p63 activation by HIF1α
Background Redox signaling caused by knockdown (KD) of Glutathione Peroxidase 2
(GPx2) in the PyMT mammary tumour model promotes metastasis via phenotypic and …
(GPx2) in the PyMT mammary tumour model promotes metastasis via phenotypic and …
Complex and variable regulation of ΔNp63 and TAp63 by TGFβ has implications for the dynamics of squamous cell epithelial to mesenchymal transition
TGFβ has roles in inflammation, wound healing, epithelial to mesenchymal transition (EMT),
and cancer stem cell states, and acts as a tumor suppressor gene for squamous cell …
and cancer stem cell states, and acts as a tumor suppressor gene for squamous cell …
[HTML][HTML] Blue light promotes conjunctival epithelial-mesenchymal transition and collagen deposition through ITGB4
Q Yang, K Chen, S Chen, Y Wang, Y Xia, J Chen… - Ecotoxicology and …, 2025 - Elsevier
The increasing prevalence of LED technology heightened blue light (BL) exposure, raising
concerns about its long-term effects on ocular health. This study investigated the …
concerns about its long-term effects on ocular health. This study investigated the …