[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Mechanistic links between obesity, diabetes, and blood pressure: role of perivascular adipose tissue

SN Saxton, BJ Clark, SB Withers… - Physiological …, 2019 - journals.physiology.org
Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets

F Jiang, J Yang, Y Zhang, M Dong, S Wang… - Nature Reviews …, 2014 - nature.com
The renin–angiotensin system (RAS) has pivotal roles in the regulation of normal physiology
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …

The renin-angiotensin-aldosterone system and its therapeutic targets

KMM Colafella, DM Bovée, AHJ Danser - Experimental eye research, 2019 - Elsevier
The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the regulation of
blood pressure and body fluid homeostasis and is a mainstay for the treatment of …

ACE inhibition, ACE2 and angiotensin-(1⿿ 7) axis in kidney and cardiac inflammation and fibrosis

ACS e Silva, MM Teixeira - Pharmacological research, 2016 - Elsevier
Abstract The Renin Angiotensin System (RAS) is a pivotal physiological regulator of heart
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …

Angiotensin-(1–7)

RA Santos - Hypertension, 2014 - Am Heart Assoc
Santos Cardiovascular Actions of Angiotensin-(1–7) 1139 in caveolin 3 expression and a
decrease in heat shock protein 90. 28 These 2 alterations may lead to a decrease in eNOS …

Mas and its related G protein–coupled receptors, Mrgprs

M Bader, N Alenina, MA Andrade-Navarro… - Pharmacological …, 2014 - ASPET
The Mas-related G protein–coupled receptors (Mrgprs or Mas-related genes) comprise a
subfamily of receptors named after the first discovered member, Mas. For most Mrgprs …

[HTML][HTML] Novel RAAS agonists and antagonists: clinical applications and controversies

CA Romero, M Orias, MR Weir - Nature Reviews Endocrinology, 2015 - nature.com
The renin–angiotensin–aldosterone system (RAAS) regulates blood pressure homeostasis
and vascular injury and repair responses. The RAAS was originally thought to be an …

Angiotensin-(1-7), adipokines and inflammation

D de Farias Lelis, DF de Freitas, AS Machado… - Metabolism, 2019 - Elsevier
Nowadays the adipose tissue is recognized as one of the most critical endocrine organs
releasing many adipokines that regulate metabolism, inflammation and body homeostasis …

Modulation of glucose metabolism by the renin-angiotensin-aldosterone system

GA Favre, VLM Esnault… - American Journal of …, 2015 - journals.physiology.org
The renin-angiotensin-aldosterone system (RAAS) is an enzymatic cascade functioning in a
paracrine and autocrine fashion. In animals and humans, RAAS intrinsic to tissues …