Spatially distinguished, multiplex nucleic acid analysis of biological specimens
J Frisén, P Ståhl, J Lundeberg, GM Cann… - US Patent …, 2020 - Google Patents
A method for spatially tagging nucleic acids of a biological specimen, including steps of (a)
providing a solid support comprising different nucleic acid probes that are randomly located …
providing a solid support comprising different nucleic acid probes that are randomly located …
Nucleic acid constructs and methods of use
MS Chee - US Patent 9,783,847, 2017 - Google Patents
The present invention provides oligonucleotide constructs, sets of such oligonucleotide
constructs, and methods of using such oligonucleotide constructs to provide validated …
constructs, and methods of using such oligonucleotide constructs to provide validated …
Methods and systems for determining spatial patterns of biological targets in a sample
MS Chee, DA Routenberg - US Patent 10,774,372, 2020 - Google Patents
The present disclosure provides methods and assay systems for use in spatially encoded
biological assays, including assays to determine a spatial pattern of abundance, expres …
biological assays, including assays to determine a spatial pattern of abundance, expres …
Spatially encoded biological assays
MS Chee - US Patent 10,308,982, 2019 - Google Patents
The present invention provides assays and assay systems for use in spatially encoded
biological assays. The invention provides an assay system comprising an assay capable of …
biological assays. The invention provides an assay system comprising an assay capable of …
Nucleic acid constructs and methods of use
MS Chee - US Patent 10,266,883, 2019 - Google Patents
The present invention provides oligonucleotide constructs, sets of such oligonucleotide
constructs, and methods of using such oligonucleotide constructs to provide validated …
constructs, and methods of using such oligonucleotide constructs to provide validated …
Nucleic acid constructs and methods of use
MS Chee - US Patent 10,000,800, 2018 - Google Patents
The present invention provides oligonucleotide constructs, sets of such oligonucleotide
constructs, and methods of using such oligonucleotide constructs to provide validated …
constructs, and methods of using such oligonucleotide constructs to provide validated …
Nucleic acid constructs and methods of use
MS Chee - US Patent 10,501,793, 2019 - Google Patents
The present invention provides oligonucleotide constructs, sets of such oligonucleotide
constructs, and methods of using such oligonucleotide constructs to provide validated …
constructs, and methods of using such oligonucleotide constructs to provide validated …
Spatially encoded biological assays
MS Chee - US Patent 10,494,667, 2019 - Google Patents
The present invention provides assays and assay systems for use in spatially encoded
biological assays. The invention provides an assay system comprising an assay capable of …
biological assays. The invention provides an assay system comprising an assay capable of …
Nucleic acid constructs and methods of use
MS Chee - US Patent 10,266,884, 2019 - Google Patents
5, 512, 439 A 6, 013, 440 A 6, 143, 496 A 6, 153, 389 A 6, 210, 894 B1 6, 258, 558 B1 6,
261, 804 B1 6, 281, 804 B1 6, 344, 316 B1 6, 404, 907 B1 6, 416, 950 B1 6, 485, 982 B1 6 …
261, 804 B1 6, 281, 804 B1 6, 344, 316 B1 6, 404, 907 B1 6, 416, 950 B1 6, 485, 982 B1 6 …
Nucleic acid constructs and methods of use
MS Chee - US Patent 10,119,165, 2018 - Google Patents
The present invention provides oligonucleotide constructs, sets of such oligonucleotide
constructs, and methods of using such oligonucleotide constructs to provide validated …
constructs, and methods of using such oligonucleotide constructs to provide validated …