The roles of matrix metalloproteinases and their inhibitors in human diseases
GA Cabral-Pacheco, I Garza-Veloz… - International journal of …, 2020 - mdpi.com
Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …
remodeling endopeptidases that have the capacity to degrade almost every component of …
Matrix metalloproteinases, vascular remodeling, and vascular disease
X Wang, RA Khalil - Advances in pharmacology, 2018 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …
Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates
AC Newby - Cardiovascular research, 2006 - academic.oup.com
Intimal thickening occurs in blood vessels in response to injury or atherosclerosis. The
balance of migration and proliferation of vascular smooth muscle cells (VSMC) over death …
balance of migration and proliferation of vascular smooth muscle cells (VSMC) over death …
Matrix metalloproteinase inhibitors as investigational and therapeutic tools in unrestrained tissue remodeling and pathological disorders
J Liu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …
Novel functions of TIMPs in cell signaling
R Chirco, XW Liu, KK Jung, HRC Kim - Cancer and Metastasis Reviews, 2006 - Springer
Tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of matrix
metalloproteinases (MMPs) and the balance between MMPs/TIMPs regulates the …
metalloproteinases (MMPs) and the balance between MMPs/TIMPs regulates the …
Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease
MM Benjamin, RA Khalil - … Inhibitors: Specificity of Binding and Structure …, 2012 - Springer
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade various
components of the extracellular matrix (ECM). MMPs could also regulate the activity of …
components of the extracellular matrix (ECM). MMPs could also regulate the activity of …
Matrix metalloproteinases: influence on smooth muscle cells and atherosclerotic plaque stability
JL Johnson - Expert review of cardiovascular therapy, 2007 - Taylor & Francis
Atherosclerotic plaque rupture, with subsequent occlusive thrombosis, is the underlying
cause of most cases of sudden cardiac death. Matrix metalloproteinases (MMPs) are thought …
cause of most cases of sudden cardiac death. Matrix metalloproteinases (MMPs) are thought …
Tissue inhibitors of metalloproteinases (TIMPs): their biological functions and involvement in oral disease
J Verstappen, JW Von den Hoff - Journal of dental research, 2006 - journals.sagepub.com
Several families of enzymes are responsible for the degradation of extracellular matrix
(ECM) proteins during the remodeling of tissues. An important family of such enzymes is that …
(ECM) proteins during the remodeling of tissues. An important family of such enzymes is that …
Mechanisms of pericyte recruitment in tumour angiogenesis: a new role for metalloproteinases
Pericytes occur in tumour blood vessels and are critical for the development of a functional
vascular network. Targeting tumour pericytes is a promising anti-angiogenic therapy but …
vascular network. Targeting tumour pericytes is a promising anti-angiogenic therapy but …
Stages of wound healing and their clinical relevance
G Hosgood - Veterinary Clinics: Small Animal Practice, 2006 - vetsmall.theclinics.com
Chemotactic for leukocytes, macrophages, lymphocytes, fibroblasts, and smooth muscle
cells Stimulates TIMP synthesis, epithelial cell migration, angiogenesis, and fibroplasia …
cells Stimulates TIMP synthesis, epithelial cell migration, angiogenesis, and fibroplasia …