Breast cancer: Biology, biomarkers, and treatments

K Barzaman, J Karami, Z Zarei, A Hosseinzadeh… - International …, 2020 - Elsevier
During the past recent years, various therapies emerged in the era of breast cancer. Breast
cancer is a heterogeneous disease in which genetic and environmental factors are involved …

Cancer overdiagnosis: a biological challenge and clinical dilemma

S Srivastava, EJ Koay, AD Borowsky… - Nature Reviews …, 2019 - nature.com
For cancer screening to be successful, it should primarily detect cancers with lethal potential
or their precursors early, leading to therapy that reduces mortality and morbidity. Screening …

Extracellular vesicles from triple negative breast cancer promote pro-inflammatory macrophages associated with better clinical outcome

M Tkach, J Thalmensi, E Timperi… - Proceedings of the …, 2022 - National Acad Sciences
Tumor associated macrophages (TAMs), which differentiate from circulating monocytes, are
pervasive across human cancers and comprise heterogeneous populations. The …

Breast cancer chemo-immunotherapy through liposomal delivery of an immunogenic cell death stimulus plus interference in the IDO-1 pathway

J Lu, X Liu, YP Liao, X Wang, A Ahmed, W Jiang, Y Ji… - ACS …, 2018 - ACS Publications
Immunotherapy provides the best approach to reduce the high mortality of metastatic breast
cancer (BC). We demonstrate a chemo-immunotherapy approach, which utilizes a liposomal …

[HTML][HTML] Metabolic crosstalk in the breast cancer microenvironment

AS Dias, CR Almeida, LA Helguero, IF Duarte - European Journal of …, 2019 - Elsevier
During tumorigenesis, breast tumour cells undergo metabolic reprogramming, which
generally includes enhanced glycolysis, tricarboxylic acid cycle activity, glutaminolysis and …

[HTML][HTML] Overview of recent advances in metastatic triple negative breast cancer

D O'Reilly, M Al Sendi, CM Kelly - World journal of clinical oncology, 2021 - ncbi.nlm.nih.gov
Metastatic triple negative breast cancer (TNBC) has an aggressive phenotype with a
predilection for visceral organs and brain. Best responses to chemotherapy are …

Molecular intrinsic versus clinical subtyping in breast cancer: A comprehensive review

A Szymiczek, A Lone, MR Akbari - Clinical genetics, 2021 - Wiley Online Library
Breast cancer is a heterogeneous disease manifesting diversity at the molecular,
histological and clinical level. The development of breast cancer classification was centered …

Breast cancer immunotherapy: Current and novel approaches

K Barzaman, S Moradi-Kalbolandi… - International …, 2021 - Elsevier
The crucial role of the immune system in the progression/regression of breast cancer (BC)
should always be taken into account. Various immunotherapy approaches have been …

High expression of cuproptosis-related SLC31A1 gene in relation to unfavorable outcome and deregulated immune cell infiltration in breast cancer: an analysis based …

L Li, L Li, Q Sun - BMC bioinformatics, 2022 - Springer
Cuproptosis induction represents a promising alternative for immunotherapies and targeted
therapies in breast cancer. This study aimed to investigate the prognostic and biological …

Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics

Y Cen, L Chen, Z Liu, Q Lin, X Fang, H Yao… - Cell death …, 2023 - nature.com
Therapy resistance remains a huge challenge for current breast cancer treatments.
Exploring molecular mechanisms of therapy resistance might provide therapeutic targets for …