Background Genomic mutations caused by cytotoxic agents used in cancer chemotherapy
may cause secondary malignancies as well as contribute to the evolution of treatment …

Engineered nanomaterials are being developed for a variety of technological applications.
However, the increasing use of nanomaterials in society has led to concerns about their …

Aflatoxin B1 (AFB1) is a mutagen and IARC (International Agency for Research on Cancer)
Group 1 carcinogen that causes hepatocellular carcinoma (HCC). Here, we present the first …

Prediction of driver genes (tumor suppressors and oncogenes) is an essential step in
understanding cancer development and discovering potential novel treatments. We recently …

Next-generation sequencing (NGS) technology has demonstrated that the cancer genomes
are peppered with mutations. Although most somatic tumour mutations are unlikely to have …

Chemical modifications to DNA bases, including DNA adducts arising from reactions with
electrophilic chemicals, are well-known to impact cell growth, miscode during replication …

Chemical modifications of RNA molecules have gained increasing attention since evidence
emerged for their substantive roles in a range of biological processes, such as the stability …

Telomerase reactivation and immortalization are critical for human carcinoma progression.
However, little is known about the mechanisms controlling this crucial step, due in part to the …

The TATA-box binding protein associated factor 1 (TAF1) protein is a key unit of the
transcription factor II D complex that serves a vital function during transcription initiation …

Humans are frequently exposed to acrylamide, a probable human carcinogen found in
commonplace sources such as most heated starchy foods or tobacco smoke. Prior evidence …