BRCA mutations in ovarian and prostate cancer: bench to bedside

S Boussios, E Rassy, M Moschetta, A Ghose… - Cancers, 2022 - mdpi.com
Simple Summary DNA damage is one of the hallmarks of cancer. Epithelial ovarian cancer
(EOC)—especially the high-grade serous subtype—harbors a defect in at least one DNA …

Medical and surgical care of patients with mesothelioma and their relatives carrying germline BAP1 mutations

M Carbone, HI Pass, G Ak, HR Alexander Jr… - Journal of Thoracic …, 2022 - Elsevier
The most common malignancies that develop in carriers of BAP1 germline mutations include
diffuse malignant mesothelioma, uveal and cutaneous melanoma, renal cell carcinoma, and …

The multicenter cancer of pancreas screening study: impact on stage and survival

M Dbouk, BW Katona, RE Brand, A Chak… - Journal of clinical …, 2022 - ascopubs.org
PURPOSE To report pancreas surveillance outcomes of high-risk individuals within the
multicenter Cancer of Pancreas Screening-5 (CAPS5) study and to update outcomes of …

Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants

S Li, V Silvestri, G Leslie, TR Rebbeck… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE To provide precise age-specific risk estimates of cancers other than female
breast and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and …

Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO Clinical Practice Guideline☆

C Sessa, J Balmaña, SL Bober… - Annals of …, 2023 - annalsofoncology.org
Hereditary breast and ovarian cancer syndrome (HBOC) is clinically defined by family
history criteria, and molecularly defined by identification of germline pathogenic variants …

Contralateral Breast Cancer Risk Among Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2

S Yadav, NJ Boddicker, J Na, EC Polley… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE To estimate the risk of contralateral breast cancer (CBC) among women with
germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2 …

Pancreatic cancer: changing epidemiology and new approaches to risk assessment, early detection, and prevention

EM Stoffel, RE Brand, M Goggins - Gastroenterology, 2023 - Elsevier
Pancreatic cancer usually results in poor survival with limited options for treatment, as most
affected individuals present with advanced disease. Early detection of preinvasive …

Pancreatic Cancer Surveillance in Carriers of a Germline CDKN2A Pathogenic Variant: Yield and Outcomes of a 20-Year Prospective Follow-Up

DCF Klatte, B Boekestijn, MNJM Wasser… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE Pancreatic cancer surveillance in high-risk individuals may lead to detection of
pancreatic ductal adenocarcinoma (PDAC) at an earlier stage and with improved survival …

Comparison of mammography AI algorithms with a clinical risk model for 5-year breast cancer risk prediction: an observational study

VA Arasu, LA Habel, NS Achacoso, DSM Buist… - Radiology, 2023 - pubs.rsna.org
Background Although several clinical breast cancer risk models are used to guide screening
and prevention, they have only moderate discrimination. Purpose To compare selected …

[HTML][HTML] Epithelial ovarian cancer

S Sambasivan - Cancer Treatment and Research Communications, 2022 - Elsevier
Epithelial ovarian cancer is the second commonest cause of death amongst all
gynaecological cancers. Treatment is challenging because almost 75% of cases are …