In this review, we address recent advances made in pathway engineering, directed
evolution, and systems/synthetic biology approaches employed in the production and …

Daidzein and genistein are two major components of soy isoflavones. They exist abundantly
in plants and possess multiple bioactivities. In contrast, ortho-hydroxydaidzein (OHD) and …

Antibiotic growth promoters (AGPs) suppress the growth of infectious pathogens. These
pathogens negatively impact agricultural production worldwide and often cause health …

Hybrid P450 systems in which P450 monooxygenases are reconstituted with non‐native or
surrogate redox partners have become important for the engineering of this class of versatile …

黄酮类化合物是一种植物生长的次级代谢产物, 一般大多数黄酮类化合物与糖苷相结合,
使其具有较复杂的分子结构. 在自然界中, 黄酮类化合物具有抗氧化性, 抗病毒, 抗肿瘤 …

Screening of cytochrome P450 monoxygenases responsible for the regiospecific
hydroxylation of flavones, isoflavones and chalcones was attempted using a P450 library …

Regiospecific 3′‐hydroxylation reaction of daidzein was performed with CYP105D7 from
Streptomyces avermitilis MA4680 expressed in Escherichia coli. The apparent Km and kcat …

8-Hydroxydaidzein (8-OHDe) has been proven to possess some important bioactivities;
however, the low aqueous solubility and stability of 8-OHDe limit its pharmaceutical and …

CYP57B3 from Aspergillus oryzae was recently discovered to catalyze the ortho-
hydroxylation of the soyisoflavone genistein. In the present study, the gene encoding …

Soy isoflavones are naturally occurring phytochemicals, which are biotransformed into
functional derivatives through oxidative and reductive metabolic pathways of diverse …