FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost
exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces …

Human endothelial cells are multifunctional cells that line blood vessels and are capable of
secreting a variety of biologically active mediators. They normally maintain vascular …

Hematopoietic stem cells (HSCs) are uniquely capable of self-renewal and provision of all of
the mature elements of the blood and immune system throughout the lifetime of an …

Innate immune memory endows innate immune cells with antigen independent heightened
responsiveness to subsequent challenges. The durability of this response can be mediated …

Early clinical reports outlining outcomes for primarily pediatric patients undergoing UCB
transplantation, point to delayed time to hematopoietic recovery, and favorable incidence …

The activation of endothelial cells (EC) and monocyte–macrophages (Mφ) by
lipopolysaccharide (LPS) is considered an important element of the vascular injury observed …

Background Psychological stress induces rapid and long-lasting changes in blood cell
composition, implying the existence of stress-induced factors that modulate hematopoiesis …

Abstract Flt3-ligand (FL) is a cytokine that is of paramount importance in the proliferation of
primitive hematopoietic progenitors. In this study, we show that endothelial cells (EC) …

Abstract CD40 ligand (CD40L)/CD40 interactions play a central role in T-cell–dependent B-
cell activation as previously shown by in vitro studies, the phenotype of CD40L knockout …

Endothelial cells (ECs) are a critical component of the bone marrow stroma in the regulation
of haemopoiesis. Recovery of bone marrow aplasia after radiation exposure depends, in …