Oxidative stress in drug-induced liver injury (DILI): from mechanisms to biomarkers for use in clinical practice
M Villanueva-Paz, L Morán, N López-Alcántara… - Antioxidants, 2021 - mdpi.com
Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an
uncommon drug adverse reaction that can develop to conditions spanning from …
uncommon drug adverse reaction that can develop to conditions spanning from …
PharmGKB summary: very important pharmacogene information for: N:-acetyltransferase 2
EM McDonagh, S Boukouvala, E Aklillu… - Pharmacogenetics …, 2014 - journals.lww.com
Background Function and expression Arylamine N-acetyltransferases (NATs) are
xenobioticmetabolizing enzymes for which three distinct enzymatic activities have been …
xenobioticmetabolizing enzymes for which three distinct enzymatic activities have been …
NAT2 polymorphisms and susceptibility to anti-tuberculosis drug-induced liver injury: a meta-analysis
PY Wang, SY Xie, Q Hao, C Zhang… - … International journal of …, 2012 - ingentaconnect.com
BACKGROUND AND OBJECTIVE: Although a series of studies have evaluated the potential
association between N-acetyltransferase 2 (NAT2) polymorphisms and the risk of anti …
association between N-acetyltransferase 2 (NAT2) polymorphisms and the risk of anti …
Pharmacogenetic study of drug-metabolising enzyme polymorphisms on the risk of anti-tuberculosis drug-induced liver injury: a meta-analysis
Y Cai, JY Yi, CH Zhou, XZ Shen - 2012 - journals.plos.org
Background Three first-line antituberculosis drugs, isoniazid, rifampicin and pyrazinamide,
may induce liver injury, especially isoniazid. This antituberculosis drug-induced liver injury …
may induce liver injury, especially isoniazid. This antituberculosis drug-induced liver injury …
Liver injury caused by drugs: an update
G Stirnimann, K Kessebohm - Swiss medical weekly, 2010 - smw.ch
Although severe idiosyncratic drug–induced liver injury (DILI) is a rare event, it has a large
impact on the fate of affected patients and the incriminated drug. Hepatic metabolism of …
impact on the fate of affected patients and the incriminated drug. Hepatic metabolism of …
Variability in the population pharmacokinetics of isoniazid in South African tuberculosis patients
JJ Wilkins, G Langdon, H McIlleron… - British journal of …, 2011 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• The pharmacokinetic properties of
isoniazid are well characterized, having been studied in seminal work beginning in the early …
isoniazid are well characterized, having been studied in seminal work beginning in the early …
Genetic basis of drug-induced liver injury: present and future
There is considerable evidence that susceptibility to idiosyncratic drug-induced liver injury
(DILI) is genetically determined. Though genetic associations with DILI have been reported …
(DILI) is genetically determined. Though genetic associations with DILI have been reported …
Pharmacogenomics of adverse drug reactions
AK Daly - Genome medicine, 2013 - Springer
Considerable progress has been made in identifying genetic risk factors for idiosyncratic
adverse drug reactions in the past 30 years. These reactions can affect various tissues and …
adverse drug reactions in the past 30 years. These reactions can affect various tissues and …
Adverse reactions due to directly observed treatment strategy therapy in Chinese tuberculosis patients: a prospective study
X Lv, S Tang, Y Xia, X Wang, Y Yuan, D Hu, F Liu… - PloS one, 2013 - journals.plos.org
Background More than 1 million tuberculosis (TB) patients are receiving directly observed
treatment strategy (DOTS) therapy in China every year. As to the profile of adverse drug …
treatment strategy (DOTS) therapy in China every year. As to the profile of adverse drug …
Pharmacogenetic & pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients
G Yimer, N Ueda, A Habtewold, W Amogne, A Suda… - PLoS …, 2011 - journals.plos.org
Background Implication of pharmacogenetic variations and efavirenz pharmacokinetics in
concomitant efavirenz based antiviral therapy and anti-tubercular drug induced liver injury …
concomitant efavirenz based antiviral therapy and anti-tubercular drug induced liver injury …