The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian
body. It divides the seminiferous epithelium into the basal and the apical (adluminal) …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Connexins are chordate gap junction channel proteins that, by enabling direct
communication between the cytosols of adjacent cells, create a unique cell signalling …

Extracellular nucleotides and nucleosides promote a vast range of physiological responses,
via activation of cell surface purinergic receptors. Virtually all tissues and cell types exhibit …

Connexin 43 (Cx43) is a gap junction (GJ) protein widely expressed in mammalian tissues
that mediates cell-to-cell coupling. Intercellular channels comprising GJ aggregates form …

Connexins are widely distributed proteins in the body that are crucially important for heart
and brain functions. Six connexin subunits form a connexon or hemichannel in the plasma …

In recent years our understanding of connexins has advanced from viewing them simply as
proteins with a surprisingly short lifespan that form gap junction channels. Connexins are …

Gap junctions (GJs) are the only known cellular structures that allow a direct cell-to-cell
transfer of signaling molecules by forming densely packed arrays or “plaques” of hydrophilic …

Connexins are integral membrane building blocks that form gap junctions, enabling direct
cytoplasmic exchange of ions and low-molecular-mass metabolites between adjacent cells …

Diabetic nephropathy as a deleterious complication of diabetes mellitus and an important
cause of end-stage renal failure is characterized by changes in the molecular and cellular …