Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Pathophysiology and epidemiology of abdominal aortic aneurysms

IM Nordon, RJ Hinchliffe, IM Loftus… - Nature reviews …, 2011 - nature.com
Abdominal aortic aneurysms (AAAs) are found in up to 8% of men aged> 65 years, yet
usually remain asymptomatic until they rupture. Rupture of an AAA and its associated …

Inflammatory cell phenotypes in AAAs: their role and potential as targets for therapy

MA Dale, MK Ruhlman, BT Baxter - … , thrombosis, and vascular …, 2015 - Am Heart Assoc
Abdominal aortic aneurysms (AAAs) are characterized by chronic inflammatory cell
infiltration. AAA is typically an asymptomatic disease and caused≈ 15 000 deaths annually …

Risk factors for thoracic aortic dissection

Z Zhou, AC Cecchi, SK Prakash, DM Milewicz - Genes, 2022 - mdpi.com
Thoracic aortic aneurysms involving the root and/or the ascending aorta enlarge over time
until an acute tear in the intimal layer leads to a highly fatal condition, an acute aortic …

Diabetes and aortic aneurysm: current state of the art

J Raffort, F Lareyre, M Clément… - Cardiovascular …, 2018 - academic.oup.com
Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only
curative treatment available relies on surgical approaches; drug-based therapies are …

[HTML][HTML] Diabetes and abdominal aortic aneurysms

P De Rango, L Farchioni, B Fiorucci, M Lenti - European Journal of …, 2014 - Elsevier
Epidemiologic evidence suggests that patients with diabetes may have a lower incidence of
abdominal aortic aneurysm (AAA); however, the link between diabetes and AAA …

Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo

S Wang, C Zhang, M Zhang, B Liang, H Zhu, J Lee… - Nature medicine, 2012 - nature.com
Smoking is the only modifiable risk factor that is associated with the development, expansion
and rupture of abdominal aortic aneurysm (AAA). However, the causative link between …

Pathogenesis and management of abdominal aortic aneurysm

J Golledge, S Thanigaimani, JT Powell… - European Heart …, 2023 - academic.oup.com
Abdominal aortic aneurysm (AAA) causes∼ 170 000 deaths annually worldwide. Most
guidelines recommend asymptomatic small AAAs (30 to< 50 mm in women; 30 to< 55 mm in …

Role of AGEs-RAGE system in cardiovascular disease

K Fukami, S Yamagishi, S Okuda - Current pharmaceutical …, 2014 - ingentaconnect.com
Advanced glycation end products (AGEs) are a heterogenous group of molecules formed
during a non-enzymatic reaction between proteins and sugar residues. Recently, AGEs and …

[HTML][HTML] Metformin treatment status and abdominal aortic aneurysm disease progression

N Fujimura, J Xiong, EB Kettler, H Xuan… - Journal of vascular …, 2016 - Elsevier
Objective In population-based studies performed on multiple continents during the past two
decades, diabetes mellitus has been negatively associated with the prevalence and …