Advanced tools and methods for single-cell surgery

A Shakoor, W Gao, L Zhao, Z Jiang… - Microsystems & …, 2022 - nature.com
Highly precise micromanipulation tools that can manipulate and interrogate cell organelles
and components must be developed to support the rapid development of new cell-based …

Needle and biopsy robots: A review

FJ Siepel, B Maris, MK Welleweerd, V Groenhuis… - Current Robotics …, 2021 - Springer
Purpose of the review Robotics is a rapidly advancing field, and its introduction in healthcare
can have a multitude of benefits for clinical practice. Especially, applications depending on …

Achieving automated organelle biopsy on small single cells using a cell surgery robotic system

A Shakoor, M Xie, T Luo, J Hou, Y Shen… - IEEE Transactions …, 2018 - ieeexplore.ieee.org
Single cell surgery such as manipulation or removal of subcellular components or/and
organelles from single cells is increasingly used for the study of diseases and their causes in …

Microfluidic surgery in single cells and multicellular systems

KS Zhang, AV Nadkarni, R Paul, AM Martin… - Chemical …, 2022 - ACS Publications
Microscale surgery on single cells and small organisms has enabled major advances in
fundamental biology and in engineering biological systems. Examples of applications range …

Manipulation of biological cells using a robot-aided optical tweezers system

M Xie, A Shakoor, C Wu - Micromachines, 2018 - mdpi.com
This article reviews the autonomous manipulation strategies of biological cells utilizing
optical tweezers, mainly including optical direct and indirect manipulation strategies. The …

Robotic batch somatic cell nuclear transfer based on microfluidic groove

Y Liu, X Wang, Q Zhao, X Zhao… - IEEE Transactions on …, 2020 - ieeexplore.ieee.org
Somatic cell nuclear transfer (SCNT), which is an important procedure in cloning, has been
conducted manually for decades. The operating efficiency drops sharply in batch SCNT …

3-D image reconstruction of biological organelles with a robot-aided microscopy system for intracellular surgery

W Gao, A Shakoor, L Zhao, Z Jiang… - IEEE Robotics and …, 2018 - ieeexplore.ieee.org
Intracellular surgery suffers from a low success rate due to the lack of three-dimensional (3-
D) position feedback of selected organelles. In this study, we developed a novel robot-aided …

Research on multi-robot scheduling algorithms based on machine vision

J Li, F Yang - EURASIP Journal on Image and Video Processing, 2018 - Springer
In the multi-robot system, how to achieve effective and reasonable task coordination
between multi-robots is an important problem;, multi-robot task scheduling is the term used …

Autonomous robot-aided optical tweezer system for biological cell manipulation

M Xie - The International Journal of Advanced Manufacturing …, 2019 - Springer
Over the past few decades, optical tweezers have become a powerful tool that is widely
used in cell-based biomedical applications. Their popularity is attributed to their unique …

Automated Electrowetting-based Nanobiopsy System for Adherent Cells

M Ruan, W Hu, Y Ma, Z Zhan… - 2023 IEEE International …, 2023 - ieeexplore.ieee.org
cell nanobiopsy based on nanopipette is an effective approach to demonstrate the
heterogeneity of cells and understand the roles of organelles, mRNA, and DNA of living …