It has been a decade since it was discovered that primary cilia have an essential role in
Hedgehog (Hh) signaling in mammals. This discovery came from screens in the mouse that …

The gene encoding the secreted protein Sonic hedgehog (Shh) is expressed in the
polarizing region (or zone of polarizing activity), a small group of mesenchyme cells at the …

Abstract Development of the forebrain critically depends on the Sonic Hedgehog (Shh)
signaling pathway, as illustrated in humans by the frequent perturbation of this pathway in …

Discovery of most autosomal recessive disease-associated genes has involved analysis of
large, often consanguineous multiplex families or small cohorts of unrelated individuals with …

Understanding how and when the left–right (LR) axis is first established is a fundamental
question in developmental biology. A popular model is that the LR axis is established …

Since its initial discovery in a Drosophila mutagenesis screen, the Hedgehog pathway has
been revealed to be instrumental in the proper development of the vertebrate face …

To elucidate the role of centriolar satellites in ciliogenesis, we deleted the gene encoding
the PCM1 protein, an integral component of satellites. PCM1 null human cells show marked …

We have identified Talpid3/KIAA0586 as a component of a CP110-containing protein
complex important for centrosome and cilia function. Talpid3 assembles a ring-like structure …

Understanding how left–right (LR) asymmetry is generated in vertebrate embryos is an
important problem in developmental biology. In humans, a failure to align the left and right …

The paternal contribution to the new individual is not just limited to half the diploid genome.
Recent findings have shown that sperm delivers to the oocyte several components …