The core of the drug research and screening processes is predicting the effect of drugs prior
to human clinical trials. Due to the 2D cell culture and animal models' poor predictability, the …

The ETS-related gene (ERG) is proto-oncogene that is classified as a member of the ETS
transcription factor family, which has been found to be consistently overexpressed in about …

Mesenchymal stem cells (MSCs) are potential candidates in cell-based therapy for cartilage
repair and regeneration. However, during chondrogenic differentiation, MSCs undergo …

Over the decades, conventional in vitro culture systems and animal models have been used
to study physiology, nutrient or drug metabolisms including mechanical and …

Heterogeneous response to Enzalutamide, a second-generation androgen receptor
signaling inhibitor, is a central problem in castration-resistant prostate cancer (CRPC) …

Transcription factors (TFs) represent the most commonly deregulated DNA-binding class of
proteins associated with multiple human cancers. They can act as transcriptional activators …

The clinical utility of circulating tumor cells (CTC) as a non-invasive multipurpose biomarker
is broadly recognized. The earliest methods for enriching CTCs from whole blood rely on …

Conrad Waddington's theory of epigenetic landscape epitomize the process of cell fate and
cellular decision-making during development. Wherein the epigenetic code maintains …

Simple Summary Transcription factors (TFs) can reprogram cellular states by modulating the
expression of their target genes and establishing gene expression programs under …

The treatment of urological cancers has been significantly improved in recent years.
However, for the advanced stages of these cancers and/or for those developing resistance …